Objective: To investigate the prognostic value of Th-22 cells and related functional cytokines in patients with vitiligo. Methods: Thirty-five patients with vitiligo who admitted to the outpatient clinic from June 2016 to November 2018 in the hospital were selected as the study group. Thirty healthy controls were selected as the control group. Th-22 cells and their related cytokines were analyzed in both groups. Resylts: The levels of cytokines in Th-22 and Th-17 cells in the study group were significantly higher than those in the control group (P<0.05). The expression of Treg lymphocyte-related factors in the study group was lower than that in the control group (P<0.05). The changes in cell and factor levels in patients with vitiligo before and after treatment were significantly different (P<0.05). Conclusion: It is shown that three cells, including Th-22, Th-17 and Treg are related to each other, and they can inhibit and promote the pathogenesis of vitiligo which provides a reference for prognosis and treatment.