Th17 Cells and Tregs in HTLV-1 Infection


Th17 cells




HTLV-1 (human T-lymphotropic virus type 1) causes chronic infection of human T lymphocytes. HTLV-1 infection is known to be related to multiple diseases, including neoplastic growth of HTLV-1-infected T cells (ATL) and neoplastic inflammatory conditions, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), Sjögren’s syndrome with arthritis, polymyositis uveitis, and bronchoalveolitis. Regulatory T cells (Tregs) regulate inflammatory cells, such as Th17 cells. The purpose of this study was to evaluate Tregs and Th17 cells, as well as the expression of related transcription factors (ROR-?t and FOXP3) and cytokines (IL-10, TGF-?, IL-6, and IL-17A) in HTLV-1 infection.


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