Keywords
Macrophages
Inflammatory vesicles
Wind-Extinguishing and Phlegm-Resolving Medicine
Submitted : 2021-12-20
Accepted : 2022-01-04
Published : 2022-01-19
Abstract
Atherosclerosis is a fundamental pathological change in coronary heart disease, with vulnerable plaque formation leading to decreased plaque stability and plaque rupture, and is a major cause of acute cardiovascular events. The inflammatory response is an important mechanism in the development and progression of atherosclerosis, and plaque stability is closely related to the inflammatory response. In recent years, the role of NLRP3 inflammatory vesicles, which are involved in macrophage foaminess, in the inflammatory response to atherosclerosis has received increasing attention. Chinese medicine is able to modulate inflammatory vesicles to improve atherosclerotic plaque stability, showing good promise in the prevention and treatment of atherosclerotic vulnerable plaques. Based on the role of inflammatory vesicles in atherosclerosis and the results of previous studies that wind-extinguishing and phlegm-resolving medicine can effectively modulate the inflammatory response to intervene in the treatment of atherosclerosis, this paper aims to investigate the treatment of coronary atherosclerosis by wind-extinguishing and phlegm-resolving medicine from the direction of inflammatory vesicles.
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