Objective: To study the clinical effect of minimally invasive single-segment reduction and internal fixation in patients withÂ thoracolumbar fractures. Methods: From June 2013 to June 2014,Â 100 patients with thoracolumbar fractures were selected as theÂ subjects and they were randomly divided into observation groupÂ (50 cases) and control group (50 cases). The patients in theÂ observation group were treated with minimally invasive single-segment reduction and internal fixation. The patients in the controlÂ group were treated with short segmental fixation. The clinical effects of the two groups were compared. Results: There was noÂ significant difference in the compression rate and Cobb angleÂ between the two groups before and after operation (P> 0.05). ForÂ all patients who were followed up for the last time, the Cobb angleÂ was significantly lower in the observation group than in the controlÂ group (P <0.05). The social function, affective function andÂ physical pain score of the observation group were significantlyÂ better than the control group (P <0.05). The amount of bleeding inÂ the observation group was (250.4 Â± 41.0) ml, which wasÂ significantly lower than that in the control group (267.5 Â± 32.8) ml.Â The time required for the operation was (90.2 Â± 35.4) min, whichÂ was significantly lower than that of the control group (104.5 Â± 22.6)Â min (P <0.05). After treatment, the prognosis was 70.00% and theÂ excellent and good rate was 98.00%, which was significantly higherÂ than that of the control group (46.00%) and 78.00% (P <0.05).Â Conclusion: Thoracolumbar fractures in patients with dilated channel minimally invasive single-segment reduction and internalÂ fixation treatment can effectively repair the patient's vertebralÂ height and Cobb angle and the degree of correction after surgeryÂ was significantly better, safer and worthy of clinical recommendedÂ use.