Meta-analysis of the Effect of Shenfu Injection on Immune Function in Patients with Sepsis
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Keywords

Shenfu Injection
Sepsis
Curative effect
Meta-analysis

DOI

10.26689/jcnr.v5i6.2769

Abstract

Objective: To systematically evaluate the effects of Shenfu Injection on immune function of sepsis patients by meta-analysis. Methods: The randomized controlled trials of Shenfu Injection in the treatment of sepsis published from 2000 to February 2021 were searched in CNKI, WanFang database and VIP database. The control group was treated with routine treatment; The experimental group was treated with Shenfu Injection on the basis of routine treatment. The included literature was evaluated by Cochrane bias risk evaluation table, and Shenfu Injection was used to treat patients with sepsis with RevMan 5.3 software. The results of meta-analysis were as reported. Conclusion: However, due to the limitation of the quality and quantity of the included research, multi center, large sample volume and high-quality RCT are still needed to verify the research results.

References

Hu GY, Hu YK, Hu YR, et al., 2019, Research Progress of Immune Regulation of Traditional Chinese Medicine on Sepsis. Journal of Emergency in Traditional Chinese Medicine, 28(05): 930-933.

Tarsilla M, 2008, Cochrane Handbook for Systematic Reviews of Interventions. Journal of Multidisciplinary Evaluation, 6: 142-148.

Lei LM, Lan X, Kao Y, et al., 2016, Effects of Shenfu Injection on T Cell Subsets, Natural Kller Cells and Prognosis in Patients with Severe Trauma. Chinese Journal of General Practice, 14(05): 743-745.

Ma JQ, Bai JH, Zhu XY, 2015, Clinical Study on Shenfu Injection Combined with Ulinastatin in the Treatment of Sepsis. Drugs & Clinic, 30(11): 1367-1369.

Xu JL, Zhang N, Zhu HJ, et al., 2014, Effect of Shenfu Injection on Clinical Efficacy and Immune Function in Patients with Severe Sepsis. Zhejiang Medical Journal, 36(06): 471-474.

Li RW, Li XZ, Hao ZW, et al., 2015, Effects of Shenfu Injection Combined with Low Dose Hydrocortisone on Inflammatory Factors and Immune Function in Patients with Severe Sepsis. Journal of Clinical Pulmonary Medicine, 20(07): 1244-1247.

Zhang GG, 2015, Clinical Observation on Shenfu Injection in the Treatment of 30 Patients with Sepsis. Journal of Emergency in Traditional Chinese Medicine, 24(07): 1268-1270.

Xi XT, Zhu MG, Liu YT, et al., 2018, Effect of Shenfu Injection on Immune Function and Inflammation Marks in Patients with Sepsis. Journal of New Chinese Medicine, 50(06): 72-76.

Gentile L, Cuenca A, Efron P, et al., 2012, Persistent Inflammation and Immunosuppression. The Journal of Trauma and Acute Care Surgery, 72: 1491-1501.

Long P, Li X, Jiang LJ, et al., 2017, Clinical Immune Function Analysis of Patients with Septic Shock. Chongqing Medicine, 46(02): 198-200.

Wu TT, Yao YM, 2017, Immune Disorders of Sepsis and Its Clinical Significance. Medical Journal of Chinese People’s Liberation Army, 42(02): 95-102.

Bohannon J, Guo Y, Sherwood E, 2012, Toll-Like Receptors Expression and Interferon-? Production by NK Cells in Human Sepsis. Critical Care, London, England, 16: 185.

Guo XQ, Kong L, Fan KL, et al., 2017, Progress in Study of Treating Septic Shock with Shenfu Injection. Journal of New Chinese Medicine, 49(06): 143-145.