Keywords
Qin pain
Methotrexate
Submitted : 2021-10-31
Accepted : 2021-11-15
Published : 2021-11-30
Abstract
Objective: To study the changes of several inflammatory index mechanism factors in the clinical efficacy of tablet and methotrexate in rheumatoid arthritis. Methods: 20 patients with rheumatoid arthritis were randomly divided into observation (n =10) and control (n =10), then normal people as normal (n=10), all three groups were given methotrexate and the observation group were treated with Qin interest pain tablets. Expression of inflammatory index mechanism factors in each group. Results: After treatment, inflammatory index mechanism factors were detected; a significant decrease of IFN-g, IL-1b, IL-10, IL-37, TNF-a and other factors was found before and after combination treatment (P <0); IL-8 and IL-13 expression (P <0); the CRP, ESR score of the study group was lower than the control group (P <0.05); and the inflammatory index mechanism factors were affected by drug combination. Conclusion: Tablets combined with methotrexate in rheumatoid arthritis patients is better than methotrexate. It obviously changed the expression of the patient’s inflammatory index mechanistic factors, which has a regulatory effect on the inflammatory mechanistic factors.
References
Li Z, 2009, Rheumatoid Arthritis. People’s Health Press, Beijing, 6.
Huang Y, Liu Y, Li Z, et al., 2005, Progress in the Factors of Rheumatoid Arthritis. Journal of Difficulties, 4(5): 317-319.
Liu D, Zhang J, Chen Q, et al., 2015, Clinical Application and Research Progress of Autoimmune Antibody Profile in Rheumatoid Arthritis. Chinese Journal of Local Disease Prevention, 30(2): 102-103.
Huang B, Wang Q, Liu K, et al., 2013, Relations between TNF-a Signaling and CD4+T Cells in the Development of Rheumatoid Arthritis. Chinese Pharmacology Bulletin, 29(7): 900-903.
Liu D, Liu J, Cao T, et al., 2016, Study on Peripheral Blood CD3+T Lymphocytes and IL-6 Levels in Active Rheumatoid Arthritis. Chinese Journal of Local Disease Prevention and Control, (8): 860-861.
Rheumatology Branch, 2010, Chinese Medical Society. Guidelines for the Diagnosis and Treatment of Rheumatoid Arthritis. Chinese Journal of Rheumatism, 14(4): 265-269
Jiang Q, Jiang H, Cao W, et al., 2007, Analysis of TCM I in 475 Patients with Rheumatoid Arthritis. Journal of TCM, 48(3): 253-255.
Wan H, 2010, Progress in Chinese and Western Drug Treatment of Rheumatoid Arthritis. Journal of Practical Heart, Brain and Lung Blood Vessels, 18(9): 1379-1380.
Yu S, 2011, Effect of the Effect in 30 Cases of Rheumatoid Arthritis. Sichuan Traditional Chinese Medicine, 29(8): 80.
Huang Y, Ma W, Liu L, et al., 2012, Randomized Controlled Clinical Study of Loose External Application with Miao Medicine and Western Medicine in the Treatment of Acute Cold and Damp Blocked Rheumatoid Arthritis. Practical TCM Internal science, 26(10): l,2,12.
Zheng X, 2002, Guidelines for Clinical Research of New TCM Drugs. Beijing: China Medical Technology, 115-117.
Nie H, Zheng Y, Li R, et al., 2013, Phosphorylation of FOXP3 Controls Regulatory T Cell Function and is Inhibited by TNF-Alpha in Rheumatoid Arthritis, Nat.Med. 19: 322-328.
Meyer G, Horste Z, Wu C, et al., 2016, RBPJ Controls Development of Pathogenic TH17 Cells by Regulating IL-23 Receptor Expression, Cell Rep, 16: 392e404.
Wu C, Yosef N, Thalhamer T, et al., 2013, Induction of Pathogenic TH17 Cells by Inducible Salt-Sensing Kinase SGK1, Nature, 496: 513-517.
Wilck N, Matus MG, Kearney SM, et al., 2017, Salt-Responsive Gut Commensal Modulates TH17 Axis and Disease, Nature, 551: 585-589.
Sundstrom B, Johansson I, Rantapaa-Dahlqvist S, 2015, Interaction between Dietary Sodium and Smoking Increases the Risk for Rheumatoid Arthritis: Results from a Nested Case-Control Study. Rheumatology (Oxford), 54: 487-493.