Research Progress of Anti-tumor Effects of Curcuma zedoaria and its Active Ingredients Through Immune Regulation Mechanism


Malignant tumor
Curcuma zedoaria and its active ingredients
Immune regulation
Anti-tumor effect




The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor effects and reliable curative effects. Previous studies have found that Curcuma zedoaria and its active ingredients, such as turmeric oil, curcumol, and ?-elemene, have obvious anti-tumor effects, and they do not have the adverse reactions and side effects seen in the anti-tumor drugs of Western medicine. Based on the review and inductive analysis of related literature, we summarize in the present article the results of some researchers who investigated the anti-tumor effects of Curcuma zedoaria and its active ingredients through the immune regulation mechanism.


Chen Z, Zhang Y, 2015, The Inhibitory Effect and Mechanism of Curcuma Zedoaria Polysaccharide on Lewis Lung Cancer Mice. Chinese Journal of Gerontology, 35(7): 1925-1927.

Yao S, Liu B, Zhong Z, 2006, Experimental Study on the Effect of Elemene on Liver Cancer. Journal of Qiqihar Medical College, 27(3): 257-258.

Ni F, 2013, Study on the Immune Mechanism of ?-Elemene Combined with DC/DRibble Vaccine Against Liver Cancer in Mice. Nanjing University of Chinese Medicine.

Lin L, Shen H, Wang L, 2011, The Effect of Astragaloside IV and ?-Elemene on Enhancing Immune Function of Mouse Macrophages: An In Vitro Experimental Study. Chinese Journal of Clinical Laboratory Science, 29(2): 129-131.

Tian L, Cao Y, Peng C, et al., 2009, Clinical Observation of the Treatment of Advanced Non-Small Cell Lung Cancer Using Elemene Emulsion Combined with Chemotherapy. Chinese Journal of Clinical Medicine, 16(5): 725-727.

Tian Y, 2012, Study on the Immunogenic Apoptosis Induced by Clostridium Difficile Toxin A in Mouse Colon Cancer Cell CT26. South China University of Technology.

Zheng L, Zhang M, Li W, 2012, Research Progress on the Correlation Between TOLL-Like Receptors and Tumor Pathogenesis. Chinese Journal of Neuro-Oncology, 10(4): 286-290.

Song X, Liu H, 2020, The Role and Mechanism of Dendritic Cells Activated by the High Mobility Group Protein 1-Target of Rapamycin Pathway in Systemic Lupus Erythematosus. Chinese Journal for Clinicians, 48(7): 787-790.

Wang Y, Xu D, Zhou K, et al., 2020, Dynamic Changes of TLR4 and Intestinal Flora in the Progression of Primary Liver Cancer and Their Relationship with Prognosis. Chinese Hepatology, 25(3): 273-276.

Wu D, Wang Z, 2020, Research Progress of the Triggering Receptors Expressed on Myeloid Cells Family and the Etiology of Periodontitis. Journal of Oral and Maxillofacial Surgery, 30(1): 47-52

Huang B, Zhao J, Li H, et al., 2005, Toll-Like Receptors on Tumor Cells Facilitate Evasion of Immune Surveillance. Cancer Res, 65(12): 5009-5014.

Sato Y, Goto Y, Narita N, et al., 2009, Cancer Cells Expressing Toll-Like Receptors and the Tumor Microenvironment. Cancer Microenviron, 2(Suppl 1): 205-214.

Idoyaga J, Moreno J, Bonifaz L, 2007, Tumor Cells Prevent Mouse Dendritic Cell Maturation Induced by TLR Ligands. Cancer Immunol Immunother, 56(8): 1237-1250.

Hu Z, Xia X, Yang X, et al., 2014, Anti-Tumor Immunotherapy Based on Dendritic Cells. Journal of Guizhou Medical University, 39(6): 783-787.

Wang L, Liu Q, Sun Q, et al., 2008, TLR4 Signaling in Cancer Cells Promotes Chemoattraction of Immature Dendritic Cells via Autocrine CCL20. Biochem Biophys Res Commun, 366(3): 852-856.

Xu D, Cui N, 2013, Progress in Biotherapy of Tumors. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 19(4): 477-479.

Xu Z, Zhu S, Pan N, et al., 2018, The Effect of Curcuma zedoaria Oil Produced in Guizhou on the Secretion of Toll-Like Receptors and Related Immune Factors in Rectal Cancer SW1463 Cell Line. Chinese Journal of Experimental Traditional Medical Formulae, 24(5): 137-141.

Li H, Sun H, Li Y, et al., 2014, The Expression of TLR2 and TLR4 in Hepatocellular Carcinoma and Their Relationship with Proliferative Effect Factors. China Journal of Modern Medicine, 24(27): 1-8.

Street SE, Cretney E, Smyth MJ, 2001, Perform and Interferon-Gamma Activities Independently Control Tumor Initiation, Growth, and Metastasis. Blood, 97(1): 192-197.

Yao S, Hu F, Liu B, 2001, The Effect of Elemene on the Immune Function of Tumor-Bearing Mice After Chemotherapy. China Pharmaceuticals, 10(8): 5.

Rosenberg SA, 2014, IL-2: The First Effective Immunotherapy for Human Cancer. J Immunol, 192(12): 5451-5458.

Alokail MS, Al-Daghri NM, Mohammed AK, et al., 2014, Increased TNF-?, IL-6 and ErbB2 mRNA Expression in Peripheral Blood Leukocytes from Breast Cancer Patients. Med Oncol, 31(8): 38.

Gerber SA, Sedlacek AL, Cron KR, et al., 2013, INF-? Mediates the Anti-Tumor Effects of Radiation Therapy in a Murine Colon Tumor. Am J Pathol, 182(6): 2345-2354.

Chen Z, Xing J, Zhu J, et al., 2019, Research on the Inhibitory Effect of Curcuma zedoaria Oil on Transplanted Tumor of Ovarian Cancer in Nude Mice and the Synergistic Effect of its Combination with Cisplatin. Chinese Journal of Modern Applied Pharmacy, 36(12): 1462-1467.

Wang J, Qi H, Lu J, et al., 2014, The Effect of Ganoderma lucidum Polysaccharides on TGF-?1 Secreted by B16F10 Melanoma Cells. The Chinese Journal of Dermatovenereology, 28(11): 1101-1108.

Xu Z, Zhu S, Luo J, et al., 2016, Effects of Curcuma zedoaria Oil on Cell Proliferation and Immune Factors of Human Rectal Cancer Cell Line SW1463. Chinese Journal of Experimental Traditional Medical Formulae, 22(13): 102-106.

Moore KW, de Waal Malefyt R, Coffman RL, et al., 2001, Interleukin-10 and the Interleukin-10 Receptor. Annu Rev Immunol, 19(1): 683-765.

Yin F, Zhao Y, Yao S, 2009, Expression of Raf-1 in Hepatocellular Carcinoma Tissues. World Chinese Journal of Digestology, 17(6): 618-622.

Morikawa T, Matsuda H, Ninomiya K, et al., 2002, Medicinal Foodstuffs. XXIX. Potent Protective Effects of Sesquiterpenes and Curcumin from Zedoariae Rhiwma on Liver Injury Induced by D-galactosamine/Lipopolysaccharide or Tumor Necrosis Factor-Alpha. Biol Pharm Bull, 25(5): 627-631.

Xu L, Bu P, Chen P, et al. 2007, Biological Treatment of 13 Cases of Gastric Tumors Using Curcumol-Based Tumor Vaccine. Journal of Oncology, 13(4): 303-304.

Sun K, Wang L, Zhang Y, 2006, Dendritic Cell as Therapeutic Vaccines Against Tumors and its Role in Therapy for Hepatocellular Carcinoma. Cellular Molecular Immunology, 3(3): 197-203.

Kang K, Zhang X, Chen Z, et al., 2015, Effect of Curcuma Zedoaria Extract on the Expression of TIMP-2, TIMP-1, nm23 and p53 in Mice with Non-Melanotic Skin Cancer. Guangdong Medical Journal, 36(17): 2666-2669.