Mechanism of Macrophage Action in Osteoarthritis
PDF

Keywords

Osteoarthritis
Macrophage

DOI

10.26689/jcnr.v5i4.2287

Abstract

Osteoarthritis (OA) is the most common chronic joint disease and the main cause of pain and disability in adults (typical clinical OA characteristics), and women are more predisposed to this disease than men. About 400 million people worldwide and more than 100 million in China suffer from arthritis. OA was named the 11th largest contributor of mortality in the world, with a disability rate of as high as 53%, and is among the three major killers threatening the health of the elderly. Colloquially, OA is called the “number one disabling disease of the 21st century.” It is the main reason for the malfunctioned mobility of the elderly. Generally, women and men start to have OA at 40 and 50, respectively. Incidence rates increased dramatically between the ages of 55 and 60. The prevalence rate among older persons over 70 years of age is almost 80–90%. In addition, the disease is a chronic progressive disease, which can not only lead to the decline of life function and the reduction or even loss of quality of life, but also has an important and huge impact on health care and social costs. This disease may also demand higher economic requirements of the affected families. Until now, since the pain mechanism of the disease is not clear, there are no effective treatment methods, and surgical joint replacement is the only choice to treat the end-stage disease. This paper focuses on the role of macrophages in OA development, with particular attention to the occurrence of pain and possible mediators involved.

References

Belluzzi E, Stocco E, Pozzuoli A, et al., 2019, Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain. Biomed Res Int, 2019: 6390182.

Vos T, Flaxman AD, Naghavi M, et al., 2012, Years Lived with Disability (YLDs) for 1160 Sequelae of 289 Diseases and Injuries 1990-2010: A Systematic Analysis for the Global Burden of Disease Study 2010. Lancet, 380(9859): 2163-2196.

La Porta C, Bura SA, Negrete R, et al., 2014, Involvement of the Endocannabinoid System in Osteoarthritis Pain. Eur J Neurosci, 39(3): 485-500.

Henrotin Y, Lambert C, Richette P, 2014, Importance of Synovitis in Osteoarthritis: Evidence for the Use of Glycosaminoglycans Against Synovial Inflammation. Semin Arthritis Rheum, 43(5): 579-587.

Liu-Bryan R, 2013, Synovium and the Innate Inflammatory Network in Osteoarthritis Progression. Curr Rheumatol Rep, 15(5): 323.

Scanzello CR, Goldring SR, 2012, The Role of Synovitis in Osteoarthritis Pathogenesis. Bone, 51(2): 249-257.

Bondeson J, Blom Ab, Wainwright S, et al., 2010, The Role of Synovial Macrophages and Macrophage-Produced Mediators in Driving Inflammatory and Destructive Responses in Osteoarthritis. Arthritis Rheum. 62(3): 647-657.

De Lange-Brokaar BJE, Ioan-Facsinay A, Van Osch GJVM, et al., 2012, Synovial Inflammation, Immune Cells and Their Cytokines in Osteoarthritis: A Review. Osteoarthritis Cartilage, 20(12): 1484-1499.

Dai L, Xu C, Tang M, et al., 2003, Effects of Synovial Macrophages on Joint Destruction in Adjuvant Arthritis Rats. Chinese Journal of Pathophysiology, 7: 87-90 155.

Cao J, Chen D, 2020, Effects and Characteristics of Synovial Macrophages on Osteoarthritis. China Organization Engineering Research, 29: 4731-4736.

Kraus VB, Mcdaniel G, Huebner JL, et al., 2016, Direct In Vivo Evidence of Activated Macrophages in Human Osteoarthritis. Osteoarthritis Cartilage, 24(9): 1613-1621.

Piscaer TM, Muller C, Mindt TL, et al., 2011, Imaging of Activated Macrophages in Experimental Osteoarthritis Using Folate-Targeted Animal Single-Photon-Emission Computed Tomography/Computed Tomography. Arthritis Rheum, 63(7): 1898-1907.

De Visser HM, Korthagen NM, Muller C, et al., 2018, Imaging of Folate Receptor Expressing Macrophages in the Rat Groove Model of Osteoarthritis: Using a New DOTA-Folate Conjugate. Cartilage, 9(2): 183-191.

Daghestani HN, Pieper CF, Kraus VB. 2015, Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients with Knee Osteoarthritis. Arthritis Rheum, 67(4): 956-965.

Wu CL, McNeill J, Goon K, et al., 2017, Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice. Arthritis Rheum, 69(9): 1772-1783.

Zhang H, Lin C, Zeng C, et al., 2018, Synovial Macrophage M1 Polarisation Exacerbates Experimental Osteoarthritis Partially Through R-spondin-2. Ann Rheum Dis, 77(10): 1524-1534.

Athanasou NA, Quinn J, 1991, Immunocytochemical Analysis of Human Synovial Lining Cells: Phenotypic Relation to Other Marrow Derived Cells. Ann Rheum Dis, 50(5): 311-315.

Bloom O, Herman PE, Spungen AM, 2020, Systemic Inflammation in Traumatic Spinal Cord Injury. Exp Neurol, 325: 113143.

Zhou Q, Sun H, Yu D, et al., 2020, Mechanism of M1/M2 Polarization of Macrophages in Different Diseases. China Pharmacology Bulletin, 11: 1502-1506.

Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al., 2018, Macrophage Plasticity, Polarization, and Function in Health and Disease. J Cell Physiol, 233(9): 6425-6440. https://doi.org/10.1002/jcp.26429

Schulert GS, Fall N, Harley JB, et al., 2016, Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicrorRNA-125a-5p in Polarized Monocyte Phenotypes. Arthritis Rheumatol, 68(9): 2300-2313. https://doi.org/10.1002/art.39694

Xu Y, Xue S, Sang W, et al., 2020, Effects of Macrophage Polarization on Osteoarthritis. Chinese Journal of Bone and Joint, 9: 689-694.

Malyshev I, Malyshev Y, 2015, Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype. BioMed Research International, 2015: 341308.

Col-Araz N, Oguzkan-Balci S, Baspinar O, et al., 2012, Mannose Binding Lectin and Macrophage Migration Inhibitory Factor Gene Polymorphisms in Turkish Children with Cardiomyopathy: No Association with MBL2 Codon 54 A/B Genotype, but an Association Between MIF-173 CC Genotype. Int J Med Sci, 9(6): 506-12.

Deb, 2009, Mechanism of Macrophage Migration Inhibitory Factor on Cell Proliferation, Migration and Adhesion. Southern Medical University.