Objective: To study the effect of Stereoscopic Comprehensive of Therapy Zhuang Medicine on IL-6 in serum of patients with rheumatoid arthritis. Methods: Sixty rheumatoid arthritis patients who met the inclusion criteria were selected and randomly divided into a control group and a treatment group using a random number table. Among them, 30 cases in the control group were treated with Western medicine, and 30 cases in the treatment group were treated with Western medical and Stereoscopic Comprehensive Therapy of Zhuang Medicine. The observation period was 8 weeks. Results: After 8 weeks of treatment, the level of IL-6 in the treatment group and the control group decreased, and the treatment group was better than the control group (P<0.05). Conclusion: The Stereoscopic Comprehensive of Zhuang Medicine can reduce the level of IL-6 in the serum of patients with rheumatoid arthritis, and has a good regulating effect on the inflammation of rheumatoid arthritis.