Objective: To analyze the effect of enteral nutrition and nursing intervention in patients with indwelling nasojejunal tube in acute severe pancreatitis. Methods: Sixty cases of patients with indwelt nasojejunal tubes treated in our hospital from August 2019 to August 2020 were divided into routine group and observation group as research subjects. Patients in both groups received enteral nutrition, patients in the routine group received routine care, and patients in the observation group received quality care. The recovery time of gastrointestinal function, length of hospital stay, hospitalization cost, nutritional indicators and incidence of complications in the two groups were compared. Results: The recovery time of gastrointestinal function in observation group was lower than that in routine group, P<0.05; The length and cost of hospitalization in observation group were lower than those in routine group, P<0.05; The nutritional indexes in observation group were higher than those in routine group, P<0.05; The incidence of complications in observation group was lower than that in routine group, P<0.05. Conclusion: Quality nursing service improve the effect of enteral nutrition, so as to ensure that patients get sufficient nutritional support. Its effect is remarkable and it is worthy of widespread clinical application.