Objective: To study the secondary warehouse management system and operation mode of medical low value consumables under SPD mode. Methods: From August 2018 to August 2019, the management mode of the secondary warehouse management system of medical low value consumables was selected. According to the management method, it can be divided into the observation group and the control group. The relevant data of the observation group was based on SPD mode, and the data of the control group was based on the traditional mode. According to the improvement of the two groups of data management effect, data integration and analysis are carried out to judge the effectiveness of the SPD mode of medical low value consumables secondary warehouse management system and its working mode. Results: During the analysis of the two groups of data, the relevant data were analyzed. The data validity of the observation group was higher (94.0%), and the differences of the limitations and problems in the management process had more advantages, while the relevant data corresponding to the two groups of data had significant differences (P<0.05). Conclusion: According to the current research results, Based on the collection, storage and central management of data electronic medical record information, the secondary warehouse management system of medical low value consumables under SPD mode is connected with clinical information system and management information system, which realizes the unification, resource integration and efficient operation of different business systems in the hospital, so as to help improve the quality and efficiency of medical care, prevent and reduce medical errors, Control and reduce medical expenses.