Objective: To explore the effect of combined application of expanded polytetrafluoroethylene and autologous ear cartilage in nasal plastic surgery. Methods: 76 cases of nasal plastic surgery patients in our hospital from September 2019 to September 2020 were selected as the research objects and divided into experimental group (38 cases, treated with expanded polytetrafluoroethylene + autologous ear cartilage surgery) and control group (38 cases, treated with autologous ear cartilage surgery). The treatment effect, appearance score and complications were compared. Results: The total effective rate of the experimental group (97.37%, 37 / 38) was higher than that of the control group (78.95%, 30 / 38), P< 0.05; After treatment, the appearance score of the experimental group was (8.97 ± 0.37), which was significantly higher than that of the control group (P< 0.05); The total incidence of complications in the experimental group (5.26%, 2 / 38) was significantly lower than that in the control group (21.05%, 8 / 38), P< 0.05. Conclusion: In the process of nasal plastic surgery, the combined application of autologous ear cartilage surgery and expanded polytetrafluoroethylene has obvious effect, improves the appearance of patients, and has less postoperative complications, which is worthy of promotion.