Objective: Objective to explore the curative effect of transforaminal endoscopic surgery in the treatment of lumbar disc herniation. Methods: From October 2018 to October 2020, 36 patients with lumbar disc herniation were randomly divided into group A and group B. the curative effect, pain, lumbar function and quality of life were analyzed. Results: The curative effect of group A was 94.44%, better than that of group B 61.11%, P< 0.05; The visual analogue scale (VAS) of group A was lower than that of group B on 3D, 5D and 7d after operation (P< 0.05); The KSS of group A was higher than that of group B (P< 0.05); The score of quality of life in group A was better than that in group B (P< 0.05). Conclusion: Lumbar disc herniation patients underwent transforaminal endoscopic surgery, the effect is good, can improve lumbar function, relieve pain, improve the quality of life of patients.