Objective: This paper mainly analyzes the effect of infrared radiation combined with external application nursing on maintenance of vascular access in hemodialysis patients. Methods: A total of 150 hemodialysis patients in our hospital from December 2019 to September 2020 were divided into the conventional group and the study group, 75 cases in each group. The conventional group was given external application nursing alone, and the study group was given infrared radiation combined with external application nursing, and the effect on the maintenance of vascular access was counted. Results: After the intervention, the indexes of URR, kt / V and human albumin in the study group were higher than those in the routine group, and the indexes of ?2-mg and MIS in the study group were lower than those in the routine group, P < 0.05;The improvement of vascular elasticity and quality of life in the study group was higher than that in the conventional group, and the incidence of complications was lower than that in the conventional group, P < 0.05. Conclusion: Infrared radiation combined with external application of nursing care in hemodialysis patients with vascular access maintenance effect is significant, can effectively improve vascular elasticity.