Objective: The study was to analyze the application effect of informationized teaching method based on evidence-based nursing in surgical nursing teaching. Methods: From December 2019 to December 2020, 60 students were selected as the research objects and randomly divided into two groups, each with 30 students in the teaching group. The observation group applied informationized teaching based on evidence-based nursing method,and the control group used the traditional teaching model. The teaching effect was evaluated. Results: The test scores of subjective theoretical knowledge and objective theoretical knowledge of the observation group were significantly higher than those of the control group, and the comprehensive ability evaluation of the observation group was also higher (P<0.05). The majority of students accepted the informationized teaching method based on evidence-based nursing, and a few held a neutral or disapproval attitude. Conclusion: Informationized teaching method based on evidence based nursing can improve students' theoretical and practical levels in surgical nursing teaching, and most students also accept this teaching method, which has application value.