Objective: To evaluate the clinical effect of kyphoplasty in the treatment of multiple osteoporotic vertebral fractures in the elderly. Methods: The duration of the study was selected from January 2018 to December 2020, and 38 patients with multiple osteoporotic spinal fractures were selected for study evaluation. All patients were treated with kyphoplasty. The clinical indicators of the two groups were compared and analyzed. Results: The total effective rate was 94.7% and the complication rate was 5.3%. The height of midline, anterior and posterior vertebral body, Cobb angle, VAS score, ODI score and ADL score of 38 patients before and after treatment were compared, which were significantly better than those before treatment (P<0.05). Conclusion: The clinical effect of kyphoplasty in the treatment of elderly patients with multiple osteoporosis is significant, which can be promoted in all levels of medical institutions.