Objective: To explore the clinical application effects of perioperative nursing intervention in the treatment of patients with cerebrovascular intervention. Methods: 176 patients with cerebrovascular intervention in our hospital from October 2018 to March 2020 were selected and randomly divided into 2 groups, with 88 cases in the control group and 88 cases in the observation group. Comparative analysis of blood pressure and incidence of complications was performed. Results: During the operation, the systolic blood pressure of the observation group increased by (11.85±1.66) mmHg, and the diastolic blood pressure was (4.63±0.45) mmHg. The control group patients’ systolic blood pressure increased by (22.12±1.98) mmHg and the diastolic blood pressure was (8.36±3.69) mmHg, the two results were significantly different. The blood pressure of the patients in the control group fluctuated more; and the incidence of complications in the observation group is lower than that of the control group. The observation group’s incidence of hematoma, low back discomfort, dysuria, and insomnia and dreaminess was 2.27%, 2.27%, 1.14%, 0%, respectively, with total incidence of 5.68%; in the control group, the incidence of hematoma, low back discomfort, dysuria, insomnia and dreaminess were 6.81%, 5.68%, 3.41%, 4.55% respectively, total incidence being 20.45%. The difference between observation group and control group is obvious. Conclusion: Through perioperative nursing intervention, the recovery speed of patients can be improved, and the incidence of postoperative complications can be reduced. The mental state of the patient before the operation was adjusted, the emotions were calmed, the patient's compliance was improved, and the patient's resistive emotions were reduced. At the same time, if patients can get good nursing care after surgery, the probability of postoperative complications is reduced, so that patients have better results in surgery, and its clinical application is worthy of promotion.