Objective: To analyze the effects of continuous self-management education on the self-care ability and health behavior of patients with tumor through peripherally inserted central venous catheters (PICC). Methods: The period from August 2018 to August 2020 was used as the research time range, and the random number table method was used as the basis for grouping. 80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group (given PICC specialist nursing, and implemented continuous self-management education), and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group (return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital). The self-care ability scores, health behavior scores, and complications during intubation between both groups were analyzed. Results: (1) There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention, P>0.05; the self-care ability score and health behavior score of the research group were better than the control group after intervention, P<0.05; (2) After investigation, the incidence of complications in the research group (2.50%) was lower than that of the control group (10.00%), but there was no difference between the groups, P>0.05. Conclusion: Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation. It can urge patients to maintain good health behaviors and reduce complications. It is worthy of promotion.