Correlation between the Expression of Inflammatory Factors and the Degree of Intervertebral Disc Degeneration

Abstract

Objective: To investigate the relationship between the expression of IL-6, IL-8, IL-15, IFN-a, TNF-a and TRPC6 in the disc tissue of patients with cervical disc degeneration. Methods: The expression levels of inflammatory factors IL-6, IL-8, IL-15, IFN-a, TNF-a and TRPC6 were analyzed by RT-PCR, and the correlation between inflammatory factors and Pfirrmann grade and inflammatory factors was analyzed. Results: The mRNA expression levels of IL-6, IL-8, IL-15, TNF - a and TRPC6 were significantly higher in Pfirrmann grade IV-V than in Pfirrmann grade II-III (P< 0.05), and IFN-a expression level in IV-V intervertebral disc samples was significantly lower than that in II-III discs (P<0.05); The mRNA expression levels of IL-6, IL-8, IL-15, TNF - a and TRPC6 were positively correlated with pfirmann grading (P<0.05), IFN - a was negatively correlated with pfirmann grading (P<0.05), IL-6, IL-8, IL-15, TNF - a and TRPC6 were positively correlated with each other(P<0.05), IFN - a was negatively correlated with IL-6, IL-8, IL-15, TNF-a and TRPC6(P<0.05). Conclusion: IL-6, IL-8, IL-15, IFN-a, TNF- a and TRPC6 are closely related to the degree of cervical disc degeneration.