Objective: The influence of vertebral compression fracture on the degeneration of adjacent disc was analyzed. Methods: 88 patients with osteoporotic vertebral compression fractures admitted to the orthopedic pain department from July 2014 to July 2019 were selected as the research objects. According to the previous MRI and the improved MRI results of admission, the patients were converted into old fractures after conservative treatment. They were followed up in 3, 6 and 12 months after discharge, and the VAS score at each time point (visual acuity score) was calculated We collected and analyzed the classification of intervertebral disc degeneration and MRI index. Results: The follow-up rate was 65.9% (58/88);There were 42 cases (72.4%) of degenerative disc adjacent to the diseased vertebra, and 16 cases (27.5%) of adjacent intervertebral disc did not degenerate; VAS scores were lower at 14 days, 3 months, 6 months and 12 months after admission; The number of grade 1 of disc degeneration was lower in 6 months and 12 months than that in admission (P<0.05), and the number of grade 2, 3 and 4 was significantly higher than that in the follow-up in December (P<0.05). The difference between 6 and 12 months was not statistically significant (P>0.05); MRI index at 6 and 12 months follow-up was lower than that at admission (P<0.05). Conclusion?Through the research and analysis, we found that osteoporotic vertebral compression fracture will have a corresponding impact on the adjacent intervertebral disc, which can make the adjacent intervertebral disc degenerate.