Objective: To explore the influence of stress management program based on Neuman theory on the level of benefit finding in postoperative breast cancer patients. Methods: Using convenient sampling method, 60 postoperative breast cancer patients in the tumor ward of a hospital were selected and randomly assigned into observation group (n=30) and control group (n=30). The control group adopts the conventional postoperative psychological nursing program, and the observation group adopts the stress management program based on Neuman theory for psychological nursing. The differences in benefit finding, life quality, and medical coping strategies between the two groups before and after nursing were compared. Results: After the implementation of the two nursing programs, the level of benefit finding, life quality, and medical coping strategies of patients in the observation group were higher than those in the control group (t1=3.996, t2=4.662, t3=4.113, P?0.05); there was a statistically significant difference in the level of benefit finding, life quality, and medical coping strategies of patients before and after the implementation of the two nursing programs(P?0.05). Conclusions: The stress management strategy based on Neuman theory can improve patients’ state of psychological stress coping, play a positive role in guiding the psychology of patients after breast cancer surgery, and can be used as a reference for the psychological nursing program of postoperative patients.