Correlation Analysis of Intervertebral Disc Degeneration with HTRA1 and HAPLN1 Gene Polymorphisms

Abstract

The lumbar spine, an important part of the body's motor mechanism, is more susceptible to damage as it bears most of the body's load. Age can cause clinical manifestations such as neurological impairment, back and leg pain in the lumbar spine. External forces result in nucleus pulposus out, destruction of the intervertebral disc fibrous ring, and gradual aging and damage. Lumbar degenerative change is a common middle-aged and old-aged disease, and its clinical symptoms on the initial stage are not obvious, but it becomes more and more serious as they get older. Patients with severe lumbar degenerative changes will appear symptoms such as urinary and fecal incontinence, lower extremity numbness, back pain, and sexual dysfunction. The main reason for back pain and leg pain is the degenerative changes in the lumbar intervertebral discs, at the same time which also leads to patients' lumbar instability. This study focuses on the correlation analysis of intervertebral disc degeneration with HTRA1 and HAPLN1 gene polymorphisms.