Objective: To investigate the clinical effect of early controlled hypotensive therapy in patients with traumatic brain injury (TBI). Methods: 68 patients with acute TBI in our hospital were selected for this investigation. They were evenly divided into a control group and an observation group according to the difference of blood pressure and basic level, whose lesion area after treatment, postoperative intracranial pressure after 2d and 7d, and GCS score of prognostic quality before and after treatment were made comparison. Results: The post-treatment lesion area of the observation group was lower than that in the control group (P<0.05); the postoperative intracranial pressure after 2d and 7d of the control group was better than the observation group(P<0.05), and the same with GCS score, which has statistical significance (P<0.05). Conclusion: Early controlled hypotensive therapy has a significant clinical effect on patients with brain trauma, it can reduce the lesion area after treatment and postoperative intracranial pressure as well.