Objective: Objective To investigate the expression of SOX4 in endometrial carcinoma tissues and its relationship with clinicopathological features. Methods: The clinical and pathological data of 51 patients with pathologically diagnosed endometrial carcinoma who underwent panhysterectomy in the Wenzhou Central Hospital from March 2017 to March 2019 were retrospectively analyzed. There were 22 cases of type I endometrial carcinoma and 29cases of type ? endometrial carcinoma. The immunohistochemical expression of SOX4 was detected, and its relationship with clinicopathological parameters was analyzed. Results: Compared with the control group, SOX4 in endometrial cancer group increased significantly (P<0.05); High SOX4 expression were closely related to differentiation, clinical stage and lymph node metastasis of endometrial cancer (P<0.05). Conclusion: SOX4 is related to the occurrence and development of EC. SOX4 may be a clinical evaluation index of EC and a reference index for clinical pathological diagnosis, it is helpful for clinicians to better analyze the high risk factors of EC patients and provide new ideas for early diagnosis, prognosis evaluation and targeted treatment of EC.