Objective: To study the clinical effect of applying clinical pathway teaching method in clinical teaching of cardiology. Methods: This paper verifies and calculates that 50 interns working in cardiology department in our hospital from October 2016 to October 2019 are divided into groups and compared in the form of double-blind method. The reference group (N=25) uses traditional teaching methods, and the experimental group (N=25) uses clinical pathway teaching method. The satisfaction degree, teaching quality, theoretical assessment results, operation assessment and comprehensive assessment results of interns in the experimental group and the reference group are compared. Results: The satisfaction degree, theoretical examination result, operation examination, comprehensive examination result, improvement of team spirit, professional quality, improvement of professional ethics, standardized diagnosis and treatment, improvement of clinical problem handling ability, stimulation of learning interest and cultivation of clinical thinking of the interns in the experimental group were compared with those of the reference group(P<0.05), showing the value of statistical comparison and demonstration between data indexes. Conclusion: The application of clinical path-teaching method in clinical teaching of cardiology can improve the clinical teaching effect and teaching quality.