Objective: To investigate the effect of intensive psychological nursing on the mood and coping ways of spinal tuberculosis patients. Methods: The clinical data of 102 patients undergoing spinal tuberculosis surgery in our hospital from February 2017 to January 2020 were retrospectively analyzed. All the cases were grouped according to different nursing plans, patients who received routine care were included in the control group (n = 50), and the ones with intensive psychological care were included in the observation group (n = 52). Compare negative emotions after nursing [assessment using self-assessment scale of anxiety (SAS), depression self-assessment scale (SDS)] and solutions [assessment using medical response questionnaire (MCMQ)] of the two groups. Results: After nursing, the SAS, SDS scores, avoidance and yield scores of the two groups were reduced, and the coping scores were increased, and the change of the observation group was greater than that of the control group, the difference was statistically significant (P<0.05). Conclusion: Spinal tuberculosis surgery patients were treated with intensive psychological care, which can relieve patients' negative emotions, improve solutions and are worthy of clinical use.