Objective: To investigate the anesthetic effect of dezocine and remifentanil combined with propofol in painless artificial abortion. Methods: 90 cases in total of painless induced abortion in our hospital from May 2017 to May 2020 were retrospectively analyzed, 29 cases of propofol anesthesia (group A), 29 cases of dezocine combined with propofol anesthesia (group B), and 32 cases of remifentanil combined with propofol anesthesia (group C) were compared the anesthesia situation. Results: Compared with the cases in group A, the incidence of pain, body movement and SPO2<90% at the injection site were lower in group B and group C, the use of propofol was reduced, and the VAS scores were lower when the patients begin to awake, and the efficiency was higher than that in group A(P<0.05); there was no statistic difference in the changes of SBP, DBP and HR index data in the operation time, postoperative awake time, and preoperative, intraoperative and postoperative time points of the three groups(P>0.05). Conclusion: Dezocine and remifentanil combined with propofol for painless artificial abortion anesthesia has more significant effect than propofol anesthesia alone, which can relieve patients' pain and reduce the chance of respiratory depression.