Objective: To explore the clinical effects of Zhuang Medicine Yangxue Xiaozheng Decoction in treating the combined Ems of dampness and blood stasis in Guangxi; Methods: 100 patients with endometriosis treated in Lili Clinic of Famous Doctor, Guangxi International Zhuang Medicine Hospital from Mach 2016 to May 2017 were chosen as the research object. According to the random grouping method, patients were randomly divided into the treatment group (The Zhuang Medicine Yangxue Xiaozheng Decoction (ZYF) Group) and the control group (Chinese patent medicine SanJieZhenTongJiaoNang (SJZT) group with 50 cases in each group. After treatment, the TCM syndrome score, changes in pelvic mass size, hepatocyte growth factor (HGP) levels, and clinical effects before and after treatment were evaluated. Results: After two courses of treatment, the total effective rate of patients in the ZYF group was 88%, which were significantly better than 70% of the SJZT group. The difference was statistically significant (P <0.05). Conclusion: With a significant effect on patients with the combined Ems of dampness and blood stasis in Guangxi, Zhuang Medicine Yangxue Xiaozheng Decoction can improve the uterine cavity mass and reduce serum HGP level.