Objective: To explore the clinical features of pregnancy-related breast cancer and the related factors affecting the prognosis. Methods: The research work was carried out in our hospital from January 2018 to January 2019. In this study, 50 patients were selected as related breast cancer patients and 50 non-pregnancy related breast cancer patients were selected as control group. The clinical characteristics and prognosis of the two groups were compared and analyzed. Results: According to the incidence of pregnancy-related breast cancer, the onset of breast cancer is in pregnancy and lactation, with more than half of the total number of patients having two or more pregnancies and 74.0% of the patients having breast feeding history. In the two groups, most of the patients went to see a doctor because of palpable breast masses, and the average maximum diameter of tumors in PBC group was (5.13 ± 3.22)cm, including 5 cases accompanied by dimple sign, 7 cases accompanied by nipple depression, 8 cases accompanied by inflammatory changes of skin, 3 cases with pathological changes involving whole milk, and 27 cases (54.00%) with palpable axillary enlarged lymph nodes on the same side. The average maximum value of tumor in Non-PABC group was (3.94 ± 2.11) cm, with 5 cases accompanied by dimple sign, 4 cases accompanied by nipple depression, and 9 cases (18.00%) with palpable axillary lymph nodes on the same side. Conclusion: As far as pregnancy-related breast cancer is concerned, the clinical misdiagnosis rate is relatively high and the prognosis is poor. Prenatal examination and breast-feeding breast cancer examination are needed to ensure early detection and diagnosis. This is the key factor to ensure the survival rate of pregnancy-related breast cancer patients and has positive significance for clinical development.