Effects of Misoprostol and Oxytocin Combined with Calcium Gluconate on Delivery Time of Parturient with High-risk Postpartum Hemorrhage and Neonatal Outcomes

Abstract

Objective: To investigate the effect of misoprostol and oxytocin combined with calcium gluconate on parturient with high-risk postpartum hemorrhage. Methods: The clinical data of 80 parturient with high-risk postpartum hemorrhage who were treated in our hospital from July 2016 to July 2019 were retrospectively analyzed. According to different treatment methods, they were divided into control group (treated with misoprostol combined with oxytocin, 40 cases) and observation group (treated with misoprostol and oxytocin combined with calcium gluconate, 40 cases), compared the clinical efficacy, delivery time, postpartum hemorrhage 2 hour after delivery, postpartum hemorrhage 24 hours after delivery and Apgar score of the newborns at 1min after birth. Results: The total effective rate (95.00%) in the observation group was higher than that in the control group (77.50%), and the difference was statistically significant (P<0.05). The third delivery stage in the observation group was shorter than that in the control group, and the postpartum hemorrhage volume was less than that in the control group. The difference was statistically significant (P<0.05). There was no significant difference in Apgar score of the two groups of newborns (P>0.05). Conclusion: Misoprostol and oxytocin combined with calcium gluconate is effective in treating high-risk postpartum hemorrhage parturient, which not only can effectively reduce postpartum hemorrhage and shorten the delivery time, but also is beneficial for neonatal outcome and worthy of clinical application.