Objective: To explore the application of comfortable nursing inÂ the preparation of colonoscopy in oral magnesium sulfate, and toÂ provide scientific reference direction for nursing staff. Methods:Â 68 patients with colonoscopy were randomly divided intoÂ experimental group and control group (n = 34). In the controlÂ group, the routine nursing intervention was used, and theÂ intervention group was treated with comfortable nursingÂ intervention. Data analysis was performed using SPSS 20.0.Â Results:Â The total satisfaction score of the experimental group wasÂ (96.88 Â± 1.26), the total satisfaction score of the control group wasÂ (80.65 Â± 3.32), the test group (P < 0.05). The incidence of adverseÂ reactions in the experimental group was significantly lower thanÂ that in the control group. The incidence of adverse reactions wasÂ 5.88% in the experimental group and 23.53% in the control group.Â Conclusion: The effect of comfortable nursing on the preparationÂ of colonic gut in the oral magnesium sulfate method is relativelyÂ large.