To study on the clinical efficacy of the repairing of the toe defect of the tip of the toe artery with skin flap. 48 patients withÂ tip of toe defects who were admitted to our department fromÂ May 2014 to December 2015 were randomly divided into twoÂ groups: control group and observation group, 24 cases in eachÂ group. The patients in the control group were treated withÂ abdominal pedicle flap while the patients in the observationÂ group were treated with the toe artery skin flap for repair. TheÂ clinical curative effect of the two groups was analyzed. TheÂ total effective rate of clinical treatment was 23 (95.83%) inÂ the observation group was significantly higher than that in theÂ control group, 19 (79.16%), and the elasticity and texture ofÂ the flap were good and no obvious adverse reaction occurred.Â The difference between the two groups was significant, p<0.05. The use of the toe artery skin flap for the treatment ofÂ the tip of toe defect has a significant clinical effect, and noÂ serious adverse reactions occurred, highly safety.