Keywords
Surgical procedures
Vascular reconstruction
Chemotherapy
Submitted : 2025-12-14
Accepted : 2025-12-29
Published : 2026-01-13
Abstract
Objective: To investigate the diagnosis and treatment methods for primary leiomyosarcoma of the inferior vena cava. Methods: The clinical course of a patient with primary inferior vena cava leiomyosarcoma admitted to our department in September 2022 was retrospectively analyzed. Combined with a literature review, the clinical characteristics of inferior vena cava leiomyosarcoma were summarized. Results: The patient recovered smoothly after radical resection. However, follow-up examination at six months postoperatively revealed local tumor recurrence and hepatic metastasis. Following a multidisciplinary discussion, the patient promptly commenced treatment at the oncology center with epirubicin (50 mg/m2) and ifosfamide (2500 mg/m2). Nevertheless, severe side effects, such as hepatotoxicity, hindered timely drug administration, and the patient was lost to follow-up after the third cycle of chemotherapy. Conclusion: Radical surgical resection remains the only potentially curative treatment for patients with inferior vena cava leiomyosarcoma. However, for tumor recurrence and metastasis, a comprehensive treatment approach incorporating chemotherapy may be more effective in improving patient survival rates.
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