Objective: To explore the effectiveness of multi-modal teaching based on an online case library in the education of gene methylation combined with spiral computed tomography (CT) screening for pulmonary ground-glass opacity (GGO) nodules. Methods: From October 2023 to April 2024, 66 medical imaging students were selected and randomly divided into a control group and an observation group, each with 33 students. The control group received traditional lecture-based teaching, while the observation group was taught using a multi-modal teaching approach based on an online case library. Performance on assessments and teaching quality were analyzed between the two groups. Results: The observation group achieved higher scores in theoretical and practical knowledge compared to the control group (P < 0.05). Additionally, the teaching quality scores were significantly higher in the observation group (P < 0.05). Conclusion: Implementing multi-modal teaching based on an online case library for pulmonary GGO nodule screening with gene methylation combined with spiral CT can enhance students’ knowledge acquisition, improve teaching quality, and have significant clinical application value.
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