Keywords
External treatment of traditional Chinese medicine
Research progress
Submitted : 2024-07-10
Accepted : 2024-07-25
Published : 2024-08-09
Abstract
Cancer pain, as a common complication in patients with malignant tumors, is regarded as the fifth vital sign. The involvement of traditional Chinese medicine (TCM) in the treatment of malignant tumors has become a distinctive feature of oncology treatment in China. It is also an important component of cancer pain management. TCM analgesic treatments include various methods, such as internal medicine and external therapies. External analgesic therapies, in particular, are significant methods in TCM pain management and offer both local treatment and systemic regulation. These methods are simple, easy to perform, and non-invasive. They can enhance pain relief effects while reducing the difficulty of oral medication intake and avoiding adverse gastrointestinal reactions, providing new perspectives and approaches for cancer pain treatment with broad development prospects. This article provides a review of the external TCM therapies for cancer pain to share with peers in the field.
References
National Health Commission of the People’s Republic of China, 2018, Standard Diagnosis and Treatment of Cancer Pain (2018). Chinese Clinical Oncology, 23(10): 937–944.
Siegel RL, Miller KD, Fuchs HE, et al., 2021, Cancer Statistics 2021. CA: A Cancer Journal for Clinicians, 71(1): 7–33.
Sung H, Ferlay J, Siegel RL, et al., 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3): 209–249.
Liu ZD, Wang HM, Zhu XY, 2020, Research Progress of Applying Traditional Chinese Medicine in the Treatment of Cancer Pain. Journal of Sichuan of Traditional Chinese Medicine, 38(1): 211–213.
Wang YY, Li PW, Jia LQ, et al., 2021, Academic Thinking and Clinical Experience of Li Pei-wen in Treating Cancerous Pain. China Journal of Traditional Chinese Medicine and Pharmacy, 36(3): 1450–1452.
Ding YX, Li SL, 2021, Professor Li Su-ling’s Experience in Differentiating and Treating Cancer Pain of Primary Liver Cancer. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 31(1): 87–89.
Bao YJ, Tang YT, Jiang XC, et al., 2020, Hua Bao-jin’s Experience in Treating Cancer Pain by Tongyang Method. China Journal of Traditional Chinese Medicine and Pharmacy, 35(11): 5582–5584.
Hou GJ, Bai ZP, Pan MQ, et al., 2018, Study on Medication Principles of External Treatment of Cancer Pain with Traditional Chinese Medicine Based on Cluster Analysis. Journal of Hunan University of Chinese Medicine, 3: 292–295.
Li D, Sun RR, Li QL, et al., 2020, Acupuncture Combined with Opioid Drugs on Moderate and Severe Cancer Pain: A Randomized Controlled Trial. Chinese Acupuncture & Moxibustion, 40(3): 257–261.
He YH, Xu NG, Zhang HB, et al., 2021, Acupoint Selection for Cancer Pain: Based on Current Evidence and Delphi Method. Chinese Acupuncture & Moxibustion, 41(10): 1161–1165.
Chen XX, Yao MH, Sai JT, et al., 2020, The Study of the Analgesic Effect of Acupuncture in Cancer Pain. World Chinese Medicine, 15(15): 2346–2353.
Yang J, Wahner-Roedler DL, Zhou X, et al., 2021, Acupuncture for Palliative Cancer Pain Management: Systematic Review. BMJ Support Palliate Care, 11(3): 264–270.
Chen J, Qiao HF, Li J, et al., 2020, The Clinic Research of Back-Shu Point Moxibustion Plus Oral Oxycodone in Cancer Pain. Shaanxi Journal of Traditional Chinese Medicine, 41(1): 105–107.
Ou JB, Zhou LQ, Liang QY, 2018, Effects of Wenyang Moxibustion Combined with Three-Step Analgesia on Pain and Quality of Life in Patients with Cancer Pain. Modern Journal of Integrated Traditional Chinese and Western Medicine, 27(21): 2319–2321.
Li H, Gong WJ, Zheng YF, 2021, Clinical Study on the Treatment of Cancer Pain with Compound Chinese Honeylocust Spine Ointment. China Modern Doctor, 59(34): 97–100.
Liang YH, Zhang C, Xie AQ, et al., 2021, Clinical Observation of External Application of Shuanghuang Sanjie Powder Combined with Opioid Drugs in the Treatment of Cancer Pain. Hubei Journal of Traditional Chinese Medicine, 43(3): 42–44.
Yu YY, 2020, Clinical Study on “Aitong Powder” in Treating Mild to Moderate Cancer Pain of Liver Cancer with Qi Stagnation and Blood Stasis Type, thesis, Shandong University of Traditional Chinese Medicine.
Guo HL, 2019, Study on the Effect of Acupoint Injection on Analgesia in Patients with Liver Cancer Pain. Electronic Journal of General Stomatology, 6(26): 172–173.
Bai T, Zheng G, Hu YQ, 2019, Effects of Auricular Acupoint Injection on Pain, Anxiety, Depression and Quality of Life in Patients with Cancer Pain. Modern Journal of Integrated Traditional Chinese and Western Medicine, 28(24): 2697–2700.
Luo JH, Liu ZH, Li ZH, 2018, Clinical Effect of Zusanli Acupoint Injection of Morphine on Severe Cancer Pain. Shaanxi Journal of Traditional Chinese Medicine, 39(2): 253–255.
Jin XQ, Rao GL, 2018, Effect of Hydroxycodone Release Table Combined with Morphine in the Titration Therapy for Cancer Pain. Chinese Journal of Cancer Prevention and Treatment, 25(S1): 172–173.
Chen J, Cong X, Zhan X, et al., 2019, Effects of Parecoxib on Pain Threshold and Inflammatory Factors IL-1Beta, IL-6 and TNF-Alpha in Spinal Cord of Rats with Bone Cancer Pain. Journal of the College of Physicians and Surgeons Pakistan, 29(6): 528–531.
Zhou KX, He XT, Hu XF, et al., 2019, XPro1595 Ameliorates Bone Cancer Pain in Rats via Inhibiting p38-Mediated Glial Cell Activation and Neuroinflammation in the Spinal Dorsal Horn. Brain Research Bulletin, 2019(149): 137–147.
Ji RR, Donnelly CR, Nedergaard M, 2019, Astrocytes in Chronic Pain and Itch. Nature Reviews Neuroscience, 20(11): 667–668.
Medeiros P, Negrini-Ferrari SE, Palazzo E, et al., 2019, N-Methyl-D-Aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical Research, 44(9): 2068–2080.
Tian J, Song T, Wang H, et al., 2019, Thalidomide Alleviates Bone Cancer Pain by Down-Regulating Expressions of NF-KappaB and GFAP in Spinal Astrocytes in a Mouse Model. International Journal of Neuroscience, 129(9): 896–903.
Zhang XQ, Zhang XC, Qiu XZ, et al., 2020, Effect of Raw Bone Capsule on the Expression of OPG and RANKL in Tibia of Osteoporotic Rats. Chinese Journal of Traditional Medical Traumatology & Orthopedics, 28(8): 21–25.
Han L, Jiang J, Xue M, et al., 2020, Sonic Hedgehog Signaling Pathway Promotes Pancreatic Cancer Pain via Nerve Growth Factor. Regional Anesthesia & Pain Medicine, 45(2): 137–144.
Hui JR, Zhang N, Li M, et al., 2019, Clinical Observation on Acupuncture Combined with Three-Step Analgesic Therapy in the Treatment of 40 Cases of Cancer Pain. Journal of Traditional Chinese Medicine, 60(2): 146–149.
Xia Z, 2017, Cancer Pain Management in China: Current Status and Practice Implications Based on the ACHEON Survey. Journal of Pain Research, 2017(10): 1943–1952.
Fan LL, Tian JJ, Zhang XB, et al., 2020, Cognition on Cancer Pain Treatment of Doctors in Beichuan Area of Mianyang City. Chinese Journal of Geriatric Care, 18(2): 69–72.
Huang ZR, Su XW, Diao YF, et al., 2019, Utilization and Patient Affordability of Opioid Analgesics for Cancer Pain Treatment in Different Regions of China. Chinese Journal of Pharmacoepidemiology, 28(6): 389–394 + 399.