Expression and Clinical Significance of CMTM6 and PD-L1 in Colorectal Cancer

Abstract

Objective: To study the expression of CMTM6 in colorectal cancer tissues and explore its relationship with tumor stage, lymph node metastasis, and prognosis. Methods: All patients underwent surgical resection and histopathological examination, and the collected tissue specimens were pathologically classified and divided into 41 cases in the cancer group and 75 cases in the paracancerous group to observe and analyze the expression of CMTM6 and PD-L1. Results: There was no statistically significant difference in the comparison of gender, age, disease duration, and other data between the two groups (P > 0.05); the high expression rate of CMTM6 in the tissues of the cancer group and the 2 groups of the paracarcinoma group was 82.93% and 1.33%, respectively, with statistically significant differences (P < 0.05), and the high expression rate of PD-L1 in the tissues of the cancer group and the 2 groups of the paracarcinoma group were 85.37% and 8.00%, respectively, with statistically significant differences (P < 0.05). The relationship between high expression of CMTM6 and PD-L1 and tumor diameter, differentiation degree, distant metastasis, and lymphatic metastasis was not statistically significant when compared between groups (P > 0.05). Conclusion: CMTM6 and PD-L1 are one of the factors predicting poor prognosis of colorectal cancer, and can be used as one of the reference indexes for treatment selection of colorectal cancer patients.