Keywords
Polysaccharides
Antiviral Efficacy
COVID-19
Submitted : 2023-08-26
Accepted : 2023-09-10
Published : 2023-09-25
Abstract
Lately there has been a lot of interest worldwide in studies on the antiviral activities of marine natural secondary metabolites, notably marine polysaccharides. It has been established that polysaccharides made from marine sources and their derivatives have antiviral effects against potent viruses. Agricultural, biological, food, and pharmaceutical industries all make extensive use of goods obtained from algae. The most well-known chemical components found in algae are polysaccharides, which have been the subject of a variety of studies because of their varied bioactivities. Polysaccharides made from algae have recently risen to the top of pharmaceutical research due to their fascinating antiviral potential. Currently, COVID-19 can be prevented with vaccination, but the brown alga Sargassum wightii has several bioactive compounds that have the following qualities and may be a better option. S. wightii is one of the marine algae species that is rich in sulfated polysaccharides, the secondary metabolites which have antiviral action and the capacity to prevent viral proliferation. Fucoidan, a long-chain sulfated polysaccharide found in various brown algae, has potent antiviral effects. Additionally, sulfated polysaccharides from green algae (such as ulvans) and red algae (such as carrageenan), and lectins from red algae (such as griffithsin) have antiviral therapeutic agents against coronaviruses and other viruses. This research focuses on screening seaweeds for possible antiviral compounds to treat viral infections notably COVID-19.
References
Kolanjinathan K, Ganesh P, Saranraj P, 2014, Pharmacological Importance of Seaweeds: A Review. WJFMS, 6(1): 1–15.
Fauziee NAM, Chang LS, Wan Mustapha WA, et al., 2021, Functional Polysaccharides of Fucoidan, Laminaran and Alginate from Malaysian Brown Seaweeds (Sargassum polycystum, Turbinaria ornata and Padina boryana). Int J Biol Macromol, 167: 1135–1145.
Shi Q, Wang A, Lu Z, et al., 2017 Overview on the Antiviral Activities and Mechanisms of Marine Polysaccharides from Seaweeds. Carbohydr Res, 453–454: 1–9.
Domettila C, Joselin J, Jeeva S, 2013, Phytochemical Analysis on Some South Indian Seaweeds. JOCPR, 5(4):275–278.
Ahmadi A, Zorofchian Moghadamtousi S, Abubakar S, et al., 2017, Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review. BioMed Res Int, 2015: 825203.
Premnathan M, Chandra K, Bajpai SK, et al., 1992, A Survey of Some Indian Marine Plants for Antiviral Activity. Botanica Marina, 35: 321–324.
Roy S, 2020, Seaweed Diversity Within Intertidal Zone of Olaikuda and Vadakkadu, Rameswaram, Southeast Coast of India. Heliyon, 6(7): e04585.
Artemisia R, Nugroho AK, Setyowati EP, et al., 2019, The Properties of Brown Marine Algae Sargassum turbinarioides and Sargassum ilicifolium Collected from Yogyakarta, Indonesia. Indonesia Journal of Pharmacy, 30(1): 43–51
Wang S, Wang W, Hou L, et al., 2020, A Sulfated Glucuronorhamnan From the Green Seaweed Monostroma nitidium: Characteristics of Its Structure and Antiviral Activity. Carbohydrate Polymers, 227: 115280.
Fitton JH, Park AY, Karpiniec SS, et al., 2021, Fucoidan and Lung Function: Value in Viral Infection. Mar Drugs, 19(1): 4.
Zayed A, El-Aasr M, Ibrahim ARS, et al., 2020, Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties. Mar Drugs, 18(11): 571.
Lorbeer AJ, Lahnstein J, Bulone V, et al., 2015, Multiple-Response Optimization of the Acidic Treatment of the Brown Algae Ecklonia radiata for the Sequential Extraction of Fucoidan and Alginate. Bioresour Technol, 197: 302–309.
Zhang H, Row KH, 2015, Extraction and Separation of Polysaccharides from Laminaria japonica by Size-Exclusion Chromatography. Journal of Chromatographic Science, 53: 498–502.
Bouhlal R, Haslin C, Chermann J-C, et al., 2011, Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales). Mar Drugs, 9(7): 1187–1209.
Yu P, Sun H, 2014, Purification of a Fucoidan from Kelp Polysaccharide and Its Inhibitory Kinetics for Tyrosinase. Carbohydr Polym, 99: 278–283.
Vijayabaskar P, Shiyamala V, 2012, Antioxidant Properties of Seaweed Polyphenol from Turbinaria ornate (Turner) J. Agardh, 1848. Asian Pacific Journal of Tropical Biomedicine, 2(1): S90–S98.
Li H, Liu J, Zhang L, et al., 2016, Antioxidant Responses and Photosynthetic Behaviors of Kappaphycus alvarezii and Kappaphycus striatum (Rhodophyta, Solieriaceae) During Low Temperature Stress. Botanical Studies, 57: 21.
Morita A, Tanino Y, Ojima T, et al., 2019, Influence of Temperature on the Anti-Allergic Activity of Fucoidan Extracted from Saccharinn japonica. Food Science and Technology Research, 25(4): 607–611.
Bedoux G, Caamal-Fuentes E, Boulho R, et al., 2016, Antiviral and Cytotoxic Activities of Polysaccharides Extracted from Four Tropical Seaweed Species. Natural Product Communications, 12(6): 807–811.
Rioux L-E, Turgeon SL, Beaulieu M, 2007, Characterization of Polysaccharides Extracted from Brown Seaweeds. Carbohydrate Polymer, 69(3): 530–537.
Babahan I, Kirim B, Mehr H. Major Natural Vegetation in Coastal and Marine Wetlands: Edible Seaweeds. In Plant Communities and Their Environment. 2019, Intech Open, 1–17.
Sharma OP, Bhat TK, 2009, DPPH Antioxidant Assay Revisited. Food Chemistry, 113(4): 1202–1205.
Lee YH, Choo C, Waisundara VY, 2014, Determination of the Total Antioxidant Capacity and Quantification of Phenolic Compounds of Different Solvent Extracts of Black Mustard Seeds (Brassica nigra). International Journal of Food Properties, 18(11): 2500–2507.
Baker CN, Thornsberry C, Hawkinson RW, 1983, Inoculum Standardization in Antimicrobial Susceptibility Testing: Evaluation of Overnight Agar Cultures and the Rapid Inoculum Standardization System. J Clin Microbiol, 17(3): 450–457.
Lim SN, Cheung PCK, Ooi VEC, et al., 2002, Evaluation of Antioxidative Activity of Extracts from a Brown Seaweed, Sargassum siliquastrum. J Agri Food Chem, 50(13): 3862–3866.
Wang C-Y, Wu T-C, Hsieh S-L, et al., 2015, Antioxidant Activity and Growth Inhibition of Human Colon Cancer Cells by Crude and Purified Fucoidan Preparations Extracted from Sargassum cristaefolium. J Food Drug Anal, 23(4): 766–777.
Thanigaivel S, Vidhya Hindu S, Vijayakumar S, et al., 2015, Differential Solvent Extraction of Two Seaweeds and Their Efficacy in Controlling Aeromonas salmonicida infection in Oreochromis mossambicus: A Novel Therapeutic Approach. Aquaculture, 443: 56–64.
Huang C-Y, Wu S-J, Yang W-N, et al., 2016, Antioxidant Activities of Crude Extracts of Fucoidan Extracted from Sargassum glaucescens by a Compressional-Puffing-Hydrothermal Extraction Process. Food Chem, 197 Pt B: 1121–1129.
Agrawal N, Minj DK, Rani K, 2015, Estimation of Total Carbohydrate Present in Dry Fruits. IOSR JESTFT, 1(6): 24–27.
Redmile-Gordon MA, Armenise E, White RP, et al., 2013, A Comparison of Two Colorimetric Assays, Based Upon Lowry and Bradford Techniques, to Estimate Total Protein in Soil Extracts. Soil Biol Biochem, 67(100): 166–173.