Keywords
Esophageal varices
NLRP3 inflammasome
GP73
Correlation
Submitted : 2023-04-30
Accepted : 2023-05-15
Published : 2023-05-30
Abstract
Objective: To investigate the correlation between NOD-like receptor family protein 3 (NLRP3) inflammasome and Golgi protein 73 (GP73) levels and hepatitis B cirrhosis with esophageal varices (EV) rupture. Methods: The subjects of this study were 145 patients with hepatitis B cirrhosis and varices who were treated in our hospital in recent years. Endoscopic examination was performed on the patients. The patients were divided into two groups according to whether there was EV rupture: rupture group and non-rupture group. The correlation between plasma NLRP3 and GP73 levels and hepatitis B cirrhosis with EV rupture was analyzed. Results: Through observation, comparing the levels of NLRP3 and GP73 between the two groups, the levels of NLRP3 and GP73 were significantly higher in the rupture group than in the non-rupture group (P < 0.05). Logistic regression analysis showed that NLRP3 and GP73 levels and Child-Pugh classification were related risk factors of hepatitis B cirrhosis with EV rupture. Conclusion: NLRP3 inflammasome and GP73 levels are closely related to hepatitis B cirrhosis with EV rupture. The corresponding evaluation aids in predicting EV rupture and bleeding in patients with hepatitis B cirrhosis.
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