Effect of Mitochondrial Function of Ovarian Granulosa Cells on In Vitro Fertilization and Embryo Transfer Outcomes in Obese Polycystic Ovary Syndrome Patients

Abstract

Objective: To investigate the effect of abnormal ovarian granulosa cell metabolism on in vitro fertilization and embryo transfer (IVF-ET) outcomes in obese polycystic ovary syndrome (PCOS) patients. Methods: Patients with PCOS who met the study criteria were screened according to the inclusion criteria. A total of 32 patients with obese PCOS were recruited into the study group, and 39 patients with non-obese PCOS were recruited into the control group. The general data (age, body mass index, and years of infertility), insulin resistance index (HOMA-IR), follicle-stimulating hormone (FSH), luteinizing hormone (LH), granulosa cell mitochondrial function, and IVF-ET outcome of patients in the study group and control group were retrospectively analyzed. Results: The differences in age and years of infertility between the study group and the control group were insignificant (P > 0.05), and the body mass index (BMI) of the study group and control group was 30.5 ± 1.24 kg/m² and 22.3 ± 1.12 kg/m², respectively, in which the difference was statistically significant (P < 0.05); the HOMA-IR of the study group was significantly higher than that of the control group (P < 0.05); the reactive oxygen species (ROS) in the study group was significantly higher than that in the control group (P < 0.05), and the ATP content in the study group was significantly lower than that in the control group (P < 0.05); comparing the FSH and LH levels between the two groups, the difference was not statistically significant (P > 0.05); the rate of IVF-ET failure was significantly higher in the study group than in the control group. Conclusion: PCOS is a complex endocrine disorder, and obesity is one of the independent risk factors for the development of PCOS.