Adenoid Basal Carcinoma of the Cervix with Squamous Differentiation: A Case Report and Literature Review


Adenoid basal carcinoma of cervix
Squamous differentiation




Adenoid basal carcinoma (ABC) of the cervix is a rare and low-incidence low-grade cervical cancer. In our practice, we encountered a case of cervical ABC with squamous differentiation and high-grade squamous intraepithelial lesion (HSIL) with gland involvement in the peripheral cervix. Reviewing relevant literature and analyzing its clinical manifestations, pathological morphology, and immunohistochemical characteristics would help deepen the understanding of this malignant tumor, so as to make a comprehensive diagnosis with differential diagnosis and prevent misdiagnosis.


Baggish MS, Woodruff JD, 1966, Adenoid Basal Carcinoma of the Cervix. Obstet Gynecol, 28(2): 213–218.

van Dinh T, Woodruff JD, 1985, Adenoid Cystic and Adenoid Basal Carcinomas of the Cervix. Obstet Gynecol, 65(5): 06.

Lin B, Xu D, Fu J, et al., 2018, A Case Report of Cervical Adenoid Basal Cell Carcinoma Combined with Minimally Invasive Squamous Cell Carcinoma. Journal of Diagnostic Pathology, 25(01): 58–61.

Liang Y, Chen X, Zhou C, et al., 2016, Clinicopathological Analysis of Seven Cases of Cervical Adenoid Basal Cell Carcinoma. Chinese Journal of Pathology, 45: 329–330.

Xing D, Lu J, 2019, Distinctive Clinicopathological Features and Disease-Specific Survival of Adenoid Cystic Carcinoma and Adenoid Basal Carcinoma in the Lower Female Genital Tract. Oncol Rep, 41(3): 1769–1778.

Grayson W, Taylor LF, Cooper K, 1999, Adenoid Cystic and Adenoid-Basal Carcinoma of the Uterine Cervix: Comparative Morphologic, Mucin, and Immunohistochemical Profile of Two Rare Neoplasms of Putative Reserve Cell Origin. Am J Surg Pathol, 23(4): 448–458.

Wen X, Lu X, Yang J, 2020, A Case of Cervical Basaloid Squamous Cell Carcinoma Combined with Multiple Primary Malignant Tumors and Literature Review. International Journal of Obstetrics and Gynecology, 47(04): 478–480.

Wang L, Wang Y, Jin W, et al., 2019, Clinicopathological Analysis of Basal-Like Squamous Cell Carcinoma of the Cervix. Chinese Journal of Obstetrics and Gynecology, 54(1): 7–12.

Villada G, Kryvenko ON, Campuzano-Zuluaga G, et al., 2018, A Limited Immunohistochemical Panel to Distinguish Basal Cell Carcinoma of Cutaneous Origin from Basaloid Squamous Cell Carcinoma of the Head and Neck. Appl Immunohistochem Mol Morphol, 26(2): 126–131.

Cao M, Huai J, 2021, Clinicopathological Observation of Cervical Adenoid Cystic Carcinoma. Medical Diet and Health, 19(07): 240–242.

Shi X, Wu S, Ling Q, et al., 2015, Clinicopathological Features and Immunohistochemical Phenotypes of Cervical Adenoid Cystic Carcinoma. Journal of Concord Medical Sciences, 6(3): 197–201.

Brill LB 2nd, Kanner WA, Fehr A, et al., 2011, Analysis of MYB Expression and MYB-NFIB Gene Fusions in Adenoid Cystic Carcinoma and Other Salivary Neoplasms. Mod Pathol, 32(24): 1169–1176.

Chen J, Lin A, He H, et al., 2019, Analysis of Prognostic Factors in 155 Cases of Cervical Neuroendocrine Tumors. Fujian Medical Journal, 41(06): 36–39.

Satoh T, Takel Y, Treilleux I, et al., 2014, Gynecologic Cancer Inter-Group (GCIG) Consensus Review for Small Cell Carcinoma of the Cervix. Int J Gynecol Cancer, 24(9 Suppl 3): S102–108.

Shao X, Sun L, 2014, New Research Progress of Cervical Neuroendocrine Tumors. Shanxi Medical Journal, 43(17): 2022–2024.

Li L, Deng Q, Wang S, et al., 2022, Clinicopathological Analysis of 25 Patients with Cervical Neuroendocrine Carcinoma. China Journal of Health Inspection, 32(09): 1099–1102.

Crowder S, Tuller E, 2007, Small Cell Carcinoma of the Female Genital Tract. Semin Oncol, 34(1): 57–63.