Lung cancer is a malignant disease with high morbidity and mortality, which affects the quality of life of patients. It has become one of the most serious public health problems in the world. Most natural products have a variety of anti-tumor activities. In recent years, scholars at home and abroad have studied the anti-tumor effect and mechanism of natural products from many aspects, especially in lung cancer. In this paper, the review on the active components of natural products in the treatment of lung cancer will provide a basis for subsequent treatment of lung cancer.
Bray F, Ferlay J, Soerjomataram I, et al., 2018, Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 68(6): 394-424.
World Health Organization: International Agency for Research on Cancer, 2021, China Source: Globocan 2020, The Global Cancer Observatory.
Wu F, Wang L, Zhou C, 2021, Lung Cancer in China: Current and Prospect. Curr Opin Oncol, 33: 40-46.
Luo YH, Chiu CH, Kuo CHS, et al., 2021, Lung Cancer in Republic of China. J Thorac Oncol, 16: 519-527.
Dincsoy AB, Duman DC, 2017, Changes in Apoptosis Related Gene Expression Profiles in Cancer Cell Line Exposed to Usnic Acid Lichen Secondary Metabolite. Turkish Journal of Biology, 41: 484-93.
Feng RM, Zong YN, Cao SM, et al., 2019, Current Cancer Situation in China: Good or Bad News from the 2018 Global Cancer Statistics?. Cancer Commun (Lond), 39(1): 22.
Wei W, 2020, Prevention and Improvement Effect of Chai Hu Guizhi Soup on Adverse Effects After Chemotherapy for Digestive Tract Tumors. Clinical Research of Traditional Chinese Medicine, 12(28): 84-86.
Goncu B, Sevgi E, Hancer CG, et al., 2020, Differential Anti-Proliferative and Apoptotic Effects of Lichen Species on Human Prostate Carcinoma Cells. PLOS ONE, 15(2): e0244831.
Ling CQ, Fan J, Lin HS, et al., 2018, Clinical Practice Guidelines for the Treatment of Primary Liver Cancer with Integrative Traditional Chinese and Western Medicine. J Integr Med, 16(4): 236-248.
Fan D, He X, Li R, et al., 2019, Study on the Antitumor Effects of Ocofuran Nanoliposomes, A Naturally Active Compound. Chinese Medicinal Herb, 50(07): 1636-1640.
Rosen VM, Guerra I, McCormack M, et al., 2017, Systematic Review and Network Meta-Analysis of Bevacizumab Plus First-Line Topotecan-Paclitaxel or Cisplatin-Paclitaxel Versus Non-Bevacizumab-Containing Therapies in Persistent, Recurrent, or Metastatic Cervical Cancer. International Journal of Gynecological Cancer Official Journal of the International Gynecological Cancer Society, 27(6): 1237-1246.
Samaan TMA, Samec M, Liskova A, et al., 2019, Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer. Biomolecules, 9(12): 789.
Jimenez-Lopez J, Bravo-Caparros I, Cabeza L, et al., 2021, Paclitaxel Antitumor Effect Improvement in Lung Cancer and Prevention of the Painful Neuropathy Using Large Pegylated Cationic Liposomes. Biomedicine & Pharmacotherapy, 133: 111059.
Bunn PA, 1997, Defining the Role of Paclitaxel in Lung Cancer: Summary of Recent Studies and Implications for Future Directions. Seminars in Oncology, 24(4 Suppl 12): S12.
Zhao M, Gao T, Wang Y, 2022, Relationship between PTOV1 Expression in the Peripheral Blood of Lung Cancer Patients and Tumor Sensitivity to the Chemotherapeutic Drugs Cisplatin and Docetaxel. The Journal of Practical Cancer, 37(01): 22-24, 28.
Chen H, 2021, Clinical Analysis of Paclitaxel Combined with Cisplatin in the Treatment of Advanced Non-Small Cell Lung Cancer. Pharmaceutical Forum Journal, 42(13): 23-26, 30.
Jin C, 2017, Analysis of the Efficacy and Toxic Reactions of Paclitaxel Sequential Chemotherapy in Patients with Breast Cancer. Chinese Practical Medicine, 12(03): 108-110.
Miao YQ, Chen MS, Zhou X, et al., 2021, Chitosan Oligosaccharide Modified Liposomes Enhance Lung Cancer Delivery of Paclitaxel. Chinese Journal of Pharmacology, 42(10): 9.
Araujo AAS, De Melo MGD, Rabelo TK, et al., 2015, Review of the Biological Properties and Toxicity of Usnic Acid. Natural Product Research, 29(23): 2167-2180.
Venkata Mallavadhani U, Vanga NR, Balabhaskara Rao K, et al., 2020, Synthesis and Antiproliferative Activity of Novel (+)- Usnic Acid Analogues. J Asian Nat Prod Res, 22(6): 562-577.
Yang Y, Nguyen TT, Jeong M-H, et al., 2016, Inhibitory Activity of (+)-Usnic Acid Against Non-Small Cell Lung Cancer Cell Motility. PLOS ONE, 11(1): e0146575.
Guan S, 2020, Based on Metabolomic and Network Pharmacological Approaches Reveal Possible Mechanisms of Pine Acid for Non-Small Cell Lung Cancer, Hebei Medical University.
Singh N, Nambiar D, Kale RK, et al., 2013, Usnic Acid Inhibits Growth and Induces Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma A549 Cells. Nutrition & Cancer, 65(Supp 1): 36-43.
Qi W, Lu C, Huang H, et al., 2020, (+)-Usnic Acid Induces ROS-dependent Apoptosis vi-a Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma. International Journal of Molecular Sciences, 21(8): 2915.
Khorasanchi Z, Shafiee M, Kermanshahi F, et al., 2018, Crocus Sativus a Natural Food Coloring and Flavoring Has Potent Anti-Tumor Properties. Phytomedicine, 43: 21-27.
Chen Y, 2020, Effect of MicroRNA-381 Targeting TMEM16A on Proliferation, Migration and Invasion of Non-Small Cell Lung Cancer, Liaoning Normal University. DOI: 10.27212/d.cnki.glnsu.2020.000755
Xue S, Mu S, Zhang W, et al., 2021, Mechanism of Rargeting TMEM16A Ion Channel for the Treatment of Lung Adenocarcinoma. Chinese Science: Life Science, 51(09): 1299-1307.
Liu DD, Ye YL, Zhang J, et al., 2014, Distinct Pro-Apoptotic Properties of Zhejiang Saffron Against Human Lung Cancer Via a Caspase-8-9-3 Cascade. Asian Pac J Cancer Prev, 15(15): 6075-6080.
Chen S, Zhao S, Wang X, et al., 2015, Crocin Inhibits Cell Proliferation and Enhances Cisplatin and Pemetrexed Chemosensitivity in Lung Cancer Cells. Transl Lung Cancer Res, 4(6): 775-783. DOI: 10.3978/j.issn.2218-6751.2015.11.03
Han J, 2020, Anti-Tumor Effects and Molecular Mechanism of L.A in Lung Cancer, Zhejiang University.
Han J, Lv W, Sheng H, et al., 2019, Ecliptasaponin A Induces Apoptosis Through the Activation of ASK1/JNK Pathway and Autophagy in Human Lung Cancer Cells. Ann Transl Med, 7(20): 539. DOI: 10.21037/atm.2019.10.07
Zhang S, 2021, Mechanism of the Proliferation of Non-Small Cell Lung CLC by the Skp2 / P27 Pathway, Traditional Chinese Medicine University of Guangzhou.
Zhang H, Luo G, Zhang Y, et al., 2016, Study of Apoptosis in A549 Cells In Vitro. TCM Pharmacology and Clinical Practice, 32(06): 78-81.