Keywords
Ischemic stroke
Neuroprotection
Submitted : 2021-10-31
Accepted : 2021-11-15
Published : 2021-11-30
Abstract
Leonurus is one of the commonly used clinical drugs in traditional Chinese medicine. In recent years, leonurus has been widely used for cerebrovascular diseases. With the deepening of research, the effect of its main component, leonurine, on the central nervous system has become clearer, and its mechanism has been confirmed and explained from many aspects. For reference, this paper discusses the latest research on the neuroprotective effect of leonurine on ischemic stroke at home and abroad in recent years.
References
Peng B, Wu B, 2018, Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China 2018. Chinese Journal of Neurology, 51(09): 666-682.
Hu L, Fang R, Guo M, 2020, Knockdown of lncRNA SNHG1 Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Cell Death by Serving as a ceRNA for Mir-424 in SH-SY5Y Cells. A Journal of Progress in Neurosurgery, Neurology and Neurosciences, 42(1): 47-54.
Li Y-Y, Lin Y-K, Liu X-H, et al., 2020, Leonurine: From Gynecologic Medicine to Pleiotropic Agent. Chinese Journal of Integrative Medicine, 26(2): 152-160.
Huang L, Xu D-Q, Chen Y-Y, et al., 2021, Leonurine, a Potential Drug for the Treatment of Cardiovascular System and Central Nervous System Diseases. Brain and Behavior, 11(2): e01995.
Du S, Liu J, Liu T, et al., 2019, Discussion on Effects of Leonurine on Brain Histopathological Changes in Rats with Ischemic Stroke Based on PI3K/AKT/NF-?B Signaling Pathway. Chinese Journal of Arteriosclerosis, 27(10): 853-861.
Zhang Q-Y, Wang Z-J, Sun D-M, et al., 2017, Novel Therapeutic Effects of Leonurine on Ischemic Stroke: New Mechanisms of BBB Integrity. Oxidative Medicine and Cellular Longevity, 2017.
Jia Q, Zhen YH, Hong X, et al., 2010, Neuroprotective Effects of Leonurine on Ischemia/Reperfusion-Induced Mitochondrial Dysfunctions in Rat Cerebral Cortex. Biological and Pharmaceutical Bulletin, 33(12): 1958-1964.
Zhang Q-Y, Wang Z-J, Miao L, et al., 2019, Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function. Oxidative Medicine and Cellular Longevity, 2019.
Hu ZL, Chi H, Ding SY, 2021, Effects of Leonurine Pretreatment on Viability and Protein Expression of TLR4/NF-?B Pathway in Hypoxic/Reoxygenated Rat Cardiomyocytes. Journal of Zhengzhou University (Medical Science), 56(04): 521-525.
Du N, 2021, Protective Effect and Mechanism of Leonurine on Hypoxic-ischemic Brain Injury in Neonatal Rats, Dali University, 42.
Liu J, Zhou Q, Peng Q, et al., 2015, Study on Chemical Constituents and Antiplatelet Aggregation Activity of Leonurus Sibiricus. Chinese Traditional Patent Medicine, 37(11): 2439-2442.
Zhang X, 2015, Effects of Aromatic Compounds of Leonurus Herb on Coagulation Function in Vitro in Rats. Chinese Traditional Patent Medicine, 37(07): 1573-1575.