Keywords
Colorectal cancer
Molecular mechanisms
Submitted : 2021-06-30
Accepted : 2021-07-15
Published : 2021-07-30
Abstract
Tumor buds are usually defined as isolated single cancer cells or clusters of up to four cancer cells located at the front of invasive tumors which play an important role in the clinical pathological study of colorectal cancer. The prognostic value of tumor budding in colorectal cancer has been supported by a large amount of evidence. However, its molecular mechanism remains unclear, and it is also a research hotspot now. This paper reviews the latest research progress on the molecular mechanisms of tumor budding in colorectal cancer.
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