Keywords
Tumor
Cancer pain
Chemoradiotherapy adverse reactions
Immune regulation
Published : 2026-08-12
Abstract
Acupoint embedding therapy is a traditional Chinese external treatment method that, under the guidance of the theory of meridians and acupuncture in traditional Chinese medicine, implants absorbable thread bodies into specific acupoints and exerts therapeutic effects through continuous, gentle, long-lasting stimulation. In recent years, as the comprehensive treatment model for tumors has shifted from simply “prolonging survival” to “improving quality of life”, acupoint embedding, as an important part of integrated traditional Chinese and Western medicine treatment, has shown unique advantages in alleviating cancer pain, reducing adverse reactions of radiotherapy and chemotherapy, improving gastrointestinal function and regulating immune function. Based on relevant studies at home and abroad, this article reviews the mechanism of action, clinical application status and existing problems of acupoint embedding in adjuvant treatment of tumors, with the aim of providing references for clinical practice and in-depth research.
References
Yang R, Su D, Wang Q, et al., 2020, Selection of Thread Bodies and Surgical Methods for Acupoint Embedding Thread Therapy and Its Clinical Application Status. Minimally Invasive Medicine, 20(4): 379–384.
Zhang L, Qin W, Qin C, et al., 2024, The Effect of Acupoint Embedding Thread Combined with Jianpi Qingfei Decoction on Patients with Spleen and Lung Qi Deficiency Syndrome After Chemotherapy for Non-Small Cell Lung Cancer. International Journal of Medical and Health Care, 30(24): 4132–4136.
Cheng L, Liang X, Hou X, et al., 2022, Clinical Bibliometric Study on Key Element Characteristics of Acupoint Embedding in Recent 10 Years. Journal of Acupuncture and Moxibustion, 47(9): 830–836.
Yang C, Bao J, Li D, 2025, Changes in T-Lymphocyte Subpopulations in Patients with Colorectal Cancer Before and After Acupoint Catgut Embedding Acupuncture Observation. Open Life Sciences, 20(1): 20221060.
Zhang Q, Li L, Hou X, et al., 2023, Effects of Intestinal Thread Implantation on Macrophage CD68, Tumor Necrosis Factor-α and Interleukin-1β in the Zusanli Acupoint Area of Rats. Acupuncture Research, 48(7): 681–685. DOI:10.13702/j.1000-0607.20220177.
Hu K, 2016, Clinical Observation on the Treatment of Moderate to Severe Cancer Pain by Embedding Thread at the Back-Shu Point Combined with Three-Step Pain Relief Method. Thesis, Guangzhou University of Chinese Medicine.
Li Z, Luo C, Wu X, 2017, Effects of Warming the Kidney, Strengthening the Spleen and Benefiting Qi Combined with Embedding Thread at Zusanli Point on Recovery of Gastrointestinal Function and Immune Function in Patients After Laparoscopic Rectal Cancer Surgery. Journal of Modern Integrated Chinese and Western Medicine, 26(6): 580–583.
Lu T, Li J, Zhao Y, et al., 2020, Observation on the Effect of Rectal Infusion of Traditional Chinese Medicine Combined with Acupoint Embedding in the Prevention and Treatment of Late-Onset Diarrhea Caused by Irinotecan. Clinical Research of Chinese Medicine, 12(15): 129–131.
Bian X, Zhang H, Xu Z, 2012, Regulatory Effect of Acupoint Embedding on the Hypothalamic-Pituitary-Adrenal Axis Under Chronic Stress in Aging Model Rats. Chinese Journal of Gerontology, 32(21): 4692–4694.
Wang Y, Yang T, Sun X, 2025, Clinical Study on the Treatment of Cancer-Related Fatigue in Breast Cancer Patients with Wuzangshu Acupoint Embedding. Journal of Clinical Acupuncture and Moxibustion, 41(3): 46–51.
Chen J, Huang T, Yu J, et al., 2025, Chinese Medicine Origin and Acupoint Embedding Therapy for Chemotherapy-Induced Brain Injury in Breast Cancer. Chinese Medicine Clinical Research, 17(15): 58–61.
Gou J, Chen J, Yang C, et al., 2021, Study on the Effect of Acupoint Embedding on the Quality of Life of Patients with Bone Metastasis Cancer Pain. Journal of Shaanxi University of Chinese Medicine, 44(6): 89–92.
Lian J, Liu M, Liu X, 2024, The Effect of Moxibustion Combined with Acupoint Embedding Thread on Chemotherapy-Related Nausea/Vomiting and Quality of Life in Patients with Non-Small Cell Lung Cancer Undergoing Chemotherapy. Modern Medicine and Health, 40(23): 4061–4064 + 4070.
Zheng Q, Huang R, He L, et al., 2023, Intervention Effect of Intradermal Needle and Acupoint Embedding Thread on Chemotherapy-Induced Nausea and Vomiting in Patients with Malignant Hematological Diseases. Electronic Journal of Modern Medicine and Health Research, 7(21): 128–130.
Zhang D, Han X, Qin S, 2020, Clinical Observation on the Prevention and Treatment of Adverse Reactions After Chemotherapy for Advanced Non-Small Cell Lung Cancer by Acupoint Embedding. Shanghai Journal of Acupuncture and Moxibustion, 39(9): 1113–1117.
Wang Y, Yang T, Sun X, 2025, Clinical Study on the Treatment of Cancer-Related Fatigue in Breast Cancer Patients with Wuzangshu Acupoint Embedding. Journal of Clinical Acupuncture and Moxibustion, 41(3): 46–51.
Li Z, Luo C, Wu X, 2017, Effects of Warming the Kidney, Strengthening the Spleen and Benefiting Qi Combined with Embedding Thread at Zusanli Point on Recovery of Gastrointestinal Function and Immune Function in Patients After Laparoscopic Rectal Cancer Surgery. Journal of Modern Integrated Chinese and Western Medicine, 26(6): 580–583.
Wang Q, Luo M, Li W, et al., 2020, The Effect of Retention Enema with Ehuang Decoction Combined with Embedding Thread at Zusanli Point on Short-Term Rehabilitation and Quality of Life in Patients After Colorectal Cancer Surgery. Chinese Journal of Clinical Oncology and Rehabilitation, 27(1): 48–51.
Wu Q, Su T, Zhang Y, et al., 2026, Catgut Implantation at Acupoints Improves Anti-PD-1 Inhibitor Efficacy in Lung Cancer by Inducing Immune Responses and Remodeling the Tumor Microenvironment. Cancer Immunology, Immunotherapy, 75(4): 126.