In recent years, with the increasing pressure of life and work, the number of people suffering from anxiety disorders and depression is increasing. In addition to the manifestations of depressed mood, depressed will, slow thinking and so on, most of them are accompanied by more obvious gastrointestinal symptoms. More and more studies have proved that psycho-psychological factors are one of the primary triggers of the onset of digestive diseases. The proposed mechanism of the brain-gut axis can not only explore the pathogenesis of gastrointestinal illness from the psychological level but also provide new ideas for the treatment related to gastrointestinal disease caused by psychological factors.