Objective: To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms. Methods: The authors research work on the hospital, work time in February 2019 - February 2020, this study selected patients of cerebral aneurysms, this period are selected for treatment of 100 cases of patients, randomly divided into two groups, a group to give simple intervention, named as the control group, another group for the interventional therapy under the guidance of 3 D printing, named as experimental group, analyze the effect of two groups of patients with clinical intervention. Results: The length of hospital stay in the experimental group was shorter than that in the control group. Meanwhile, the incidence of complications and adverse reactions in the experimental group and the control group were 6.00% and 18.00%, the experimental group was better(P<0.05). Conclusion: 3D printing technology can be applied in the treatment of patients with cerebral aneurysms to provide guidance for interventional surgical treatment. It has significant effect, can reduce the incidence of complications in patients, has significant clinical effect, and can be popularized.