Objective: To explore the clinical value of color Doppler ultrasonography in the diagnosis of breast cancer. Methods: 99 cases of breast cancer patients were selected as the research object, retrospective analysis of its clinical treatment data. Results: The group of 99 patients, 97 confirmed cases, 2 cases were misdiagnosed, the diagnostic accuracy rate was 97.98%. Conclusion: Color Doppler ultrasonography in patients with breast cancer has the advantages of high accuracy, simple operation and noninvasive. It is worthy of promotion.