Expression and Clinical Significance of PKM2 and SERBP1 in Colorectal Cancer
Articles

Expression and Clinical Significance of PKM2 and SERBP1 in Colorectal Cancer

Yijie Li
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
Ying Duan
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
Zhengyi Cheng
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
Weichen Zuo
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
Juan Yang
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
Hangrong Fang
Department of Pathology, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an 710021, Shaanxi, China
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Keywords

PKM2
SERBP1
Colorectal cancer

DOI

10.26689/par.v10i1.13716

Submitted : 2026-01-05
Accepted : 2026-01-20
Published : 2026-02-04

Abstract

Objective: To investigate the expression of pyruvate kinase M2 (PKM2) and RNA binding proteins 1 (SERBP1) in colorectal cancer (CRC) and their clinical significance. Methods: A total of 101 cases of colorectal adenocarcinoma tissues and their corresponding adjacent tissues were collected from our hospital from December 2020 to December 2023. The immunohistochemical Elivision method was used to detect the expression of PKM2 and SERBP1 in CRC and corresponding adjacent tissues. The experimental data were analyzed using statistical software SPSS 27.0. Results: The expression rates of PKM2 and SERBP1 in CRC were higher than those in adjacent tissues. The expression of PKM2 was positively correlated with lymph node metastasis and TNM stage. The expression of SERBP1 was positively correlated with the degree of differentiation, lymph node metastasis, and TNM stage of CRC. Conclusion: PKM2 and SERBP1 may promote the occurrence and tumor progression of CRC, but further experimental research is still needed.

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