Objective: To analyze the therapeutic effect of laparoscopy combined with choledochoscopy in the treatment of difficult cholelithiasis. Methods: A total of 60 patients with difficult cholelithiasis admitted for treatment from January 2022 to December 2024 were selected and evenly divided into two groups using a random number table. The combined group received laparoscopy combined with choledochoscopy treatment, while the single group received laparoscopy treatment alone. The total treatment efficacy, perioperative indicators, angiotensin (Ang) levels, quality of life scores, and complication rates were compared between the two groups. Results: The total treatment efficacy in the combined group was higher than that in the single group; except for operative time, the perioperative indicators in the combined group were superior to those in the single group; the Ang levels after treatment in the combined group were lower than those in the single group, and the quality of life scores were higher (P < 0.05). The complication rate in the combined group was lower than that in the single group (P < 0.05). Conclusion: Laparoscopy combined with choedochoscopy can enhance the treatment effectiveness for patients with difficult cholelithiasis, improve perioperative indicators, regulate their Ang levels, elevate quality of life, and demonstrate high surgical safety.
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