Keywords
Liver neoplasms
Web of Science
CiteSpace
VOSviewer
Bibliometric method
Therapeutics
Submitted : 2026-01-05
Accepted : 2026-01-20
Published : 2026-02-04
Abstract
Selective internal radiation therapy using yttrium-90 has been used to treat hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and other malignant tumors that have spread to the liver locally. The authors used the bibliometric approach in response to the neoplasms, using the keyword “Yttrium 90 AND Liver Neoplasms” as a search parameter and then looked up pertinent English-language literature in the Web of Science core collection database’s self-built database through November 30, 2025. For statistical analysis and literature management, EndNote and Excel tools were utilized. In addition to co-citation and emergent keyword analysis of authors, VOSviewer and CiteSpace were utilized for social network and chronological order of countries, institutions, authors, and keywords. The aim of this study was to serve as a reference for future research by methodically sorting through the international research literature on Yttrium 90 treatment of liver neoplasms and summarizing the research status and hot trends in this field. In recent years, research focus has increasingly shifted toward high-quality, multi-center clinical trials that combine SIRT-targeted systemic therapy with hepatectomy following the descending stage. This approach is likely to remain a significant research trend in the field.
References
Cao W, Chen H, Yu Y, et al., 2021, Changing Profiles of Cancer Burden Worldwide and in China: A Secondary Analysis of the Global Cancer Statistics 2020. Chinese Medical Journal, 134(7): 783–791.
Reig M, Forner A, Rimola J, et al., 2022, BCLC Strategy for Prognosis Prediction and Treatment Recommendation: The 2022 Update. Journal of Hepatology, 76(3): 681–693.
Zhou J, Sun H, Wang Z, et al., 2020, Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition). Liver Cancer, 9(6): 682–720.
Feng X, Zhang L, Niu H, et al., 2023, Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres Followed by Anatomical Hepatectomy: A Potential Curative Strategy in Advanced Hepatocellular Carcinoma. Asia-Pacific Journal of Clinical Oncology, 20(2): 319–322.
Tzedakis S, Sebai A, Jeddou H, et al., 2023, Resection Postradioembolization in Patients with Single Large Hepatocellular Carcinoma. Annals of Surgery, 278(5): 756–762.
Mosconi C, Cacioppa L, Cappelli A, et al., 2023, Update of the Bologna Experience in Radioembolization of Intrahepatic Cholangiocarcinoma. Technology in Cancer Research & Treatment, 22: 15330338231155690.
Chiu A, Savoor R, Gordon A, et al., 2023, Yttrium-90 Radiation Segmentectomy in Oligometastatic Secondary Hepatic Malignancies. Journal of Vascular and Interventional Radiology, 34(3): 362–368.
Emmons E, Bishay S, Du L, et al., 2022, Survival and Toxicities after Yttrium-90 Transarterial Radioembolization of Metastatic Colorectal Cancer in the Resin Registry. Radiology, 305(1): 228–236.
Edeline J, Touchefeu Y, Guiu B, et al., 2020, Radioembolization Plus Chemotherapy for First-Line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial. JAMA Oncology, 6(1): 51–59.
Levillain H, Bagni O, Deroose C, et al., 2021, International Recommendations for Personalised Selective Internal Radiation Therapy of Primary and Metastatic Liver Diseases with Yttrium-90 Resin Microspheres. European Journal of Nuclear Medicine and Molecular Imaging, 48(5): 1570–1584.
Sung H, Ferlay J, Siegel R, et al., 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3): 209–249.
Cervantes A, Adam R, Roselló S, et al., 2023, Metastatic Colorectal Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up. Annals of Oncology, 34(1): 10–32.
Ilic M, Ilic I, 2024, Cancer of Colon, Rectum and Anus: The Rising Burden of Disease Worldwide from 1990 to 2019. Journal of Public Health, 46(1): 20–29.
Salem R, Gordon A, Mouli S, et al., 2016, Y90 Radioembolization Significantly Prolongs Time to Progression Compared with Chemoembolization in Patients with Hepatocellular Carcinoma. Gastroenterology, 151(6): 1155–1163.
Kennedy A, Nag S, Salem R, et al., 2007, Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium. International Journal of Radiation Oncology Biology Physics, 68(1): 13–23.
Bruix J, Sherman M, 2011, Management of Hepatocellular Carcinoma: An Update. Hepatology, 53(3): 1020–1022.
Vilgrain V, Pereira H, Assenat E, et al., 2017, Efficacy and Safety of Selective Internal Radiotherapy with Yttrium-90 Resin Microspheres Compared with Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma (Sarah): An Open-Label Randomised Controlled Phase 3 Trial. Lancet Oncology, 18(12): 1624–1636.
Siriwardena A, Serrablo A, Fretland Å, et al., 2023, The Multi-Societal European Consensus on the Terminology, Diagnosis and Management of Patients with Synchronous Colorectal Cancer and Liver Metastases: An E-AHPBA Consensus in Partnership with ESSO, ESCP, ESGAR, and CIRSE. HPB, 25(9): 985–999.
Weiner A, Gui B, Newman N, et al., 2018, Predictors of Survival after Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases. Journal of Vascular and Interventional Radiology, 29(8): 1094–1100.
Sharma N, Kappadath S, Chuong M, et al., 2022, The American Brachytherapy Society Consensus Statement for Permanent Implant Brachytherapy Using Yttrium-90 Microsphere Radioembolization for Liver Tumors. Brachytherapy, 21(5): 569–591.
Kolligs F, Arnold D, Golfieri R, et al., 2022, Factors Impacting Survival after Transarterial Radioembolization in Patients with Hepatocellular Carcinoma: Results from the Prospective CIRT Study. JHEP Reports, 5(2): 100633.
Fidelman N, Atreya C, Griffith M, et al., 2022, Phase I Prospective Trial of TAS-102 (Trifluridine and Tipiracil) and Radioembolization with 90Y Resin Microspheres for Chemo-Refractory Colorectal Liver Metastases. BMC Cancer, 22(1): 1307.
Liu C, Tadros G, Smith Q, et al., 2022, Selective Internal Radiation Therapy of Metastatic Breast Cancer to the Liver: A Meta-Analysis. Frontiers in Oncology, 12: 887653.
Dhondt E, Lambert B, Hermie L, et al., 2022, 90Y Radioembolization Versus Drug-Eluting Bead Chemoembolization for Unresectable Hepatocellular Carcinoma: Results from the TRACE Phase II Randomized Controlled Trial. Radiology, 303(3): 699–710.
Salem R, Lewandowski R, Mulcahy M, et al., 2010, Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres: A Comprehensive Report of Long-Term Outcomes. Gastroenterology, 138(1): 52–64.
Gangi A, Shah J, Hatfield N, et al., 2018, Intrahepatic Cholangiocarcinoma Treated with Transarterial Yttrium-90 Glass Microsphere Radioembolization: Results of a Single Institution Retrospective Study. Journal of Vascular and Interventional Radiology, 29(8): 1101–1108.
Binzaqr S, Debordeaux F, Blanc J, et al., 2023, Efficacy of Selective Internal Radiation Therapy for Hepatocellular Carcinoma Post-Incomplete Response to Chemoembolization. Pharmaceuticals (Basel, Switzerland), 16(12): 1676.
Lee H, Alder L, Nguyen M, et al., 2023, Long-Term Outcome Analysis of Y90 Radioembolization in Hepatocellular Carcinoma. Journal of Gastrointestinal Oncology, 14(3): 1378–1391.
Baker T, Tabrizian P, Zendejas I, et al., 2022, Conversion to Resection Post Radioembolization in Patients with HCC: Recommendations from a Multidisciplinary Working Group. HPB, 24(7): 1007–1018.
Zeng H, Zhou C, Chen X, et al., 2023, Comparison of the Efficacy and Safety of Selective Internal Radiotherapy and Sorafenib Alone or Combined for Hepatocellular Carcinoma: A Systematic Review and Bayesian Network Meta-Analysis. Clinical and Experimental Medicine, 23(6): 2141–2150.
Kaya N, Tai D, Lim X, et al., 2023, Multimodal Molecular Landscape of Response to Y90-Resin Microsphere Radioembolization Followed by Nivolumab for Advanced Hepatocellular Carcinoma. Journal for Immunotherapy of Cancer, 11(8): e007106.
Li C, He W, 2022, Comparison of Primary Liver Cancer Mortality Estimates from World Health Organization, Global Burden Disease and Global Cancer Observatory. Liver International, 42(10): 2299–2316.
Yang T, Tabrizian P, Zhang H, et al., 2017, Comparison of Patterns and Outcomes of Liver Resection for Hepatocellular Carcinoma: East Vs West. Clinical Gastroenterology and Hepatology, 15(12): 1972–1974.
Choo S, Tan W, Goh B, et al., 2016, Comparison of Hepatocellular Carcinoma in Eastern Versus Western Populations. Cancer, 122(22): 3430–3446.